Preneoplastic cells (PNCs) are found in most ptc mutants during early adulthood, but only 15% of these animals develop tumors. Although PNCs are found in mice that develop tumors, the ability of PNCs to give rise to tumors has never been demonstrated directly, and the fate of cells that ...
: existing or occurring prior to the formation of a neoplasm preneoplastic cells Dictionary Entries Near preneoplastic prenatal preneoplastic prenormal See More Nearby Entries Cite this Entry Style “Preneoplastic.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam...
A number of changes occur in preneoplastic and neoplastic cells as they progress towards a greater degree of malignancy. These alterations include genetic changes, epigenetic changes, surface alterations and alterations in intercellular interactions. In some instances, these changes are contributing factors...
(Pathology) (esp of cells) displaying characteristics that may develop into cancer Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014 ...
Background: Osteopontin (OPN) is a secreted phosphoprotein expressed by neoplastic cells involved in the malignant potential and aggressive phenotypes of h... KH Hsu,HW Tsai,PW Lin… - 《World Journal of Surgical Oncology》 被引量: 0发表: 2014年 Autocrine activation of an osteopontin-CD44-Rac...
Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear. Here we analysed the somatic variants of pan
The proliferating fraction increases evenly throughout the liver, but, in all experimental modalities, preneoplastic cells show a proliferative advantage over the phenotypically normal tissue. In each experimental group, the proliferative rate correlates with the pathological evolution. After 2 weeks of ...
In early lung cancer numerous laminin positive basement membrane like structures are situated around tumour cells. An enhanced deposition of collagen type I and III fibres could be demonstrated around tumour cell islets. The results indicate a partial loss of function in preneoplastic basal cells in...
Preneoplastic Changesdoi:10.1007/978-3-642-16483-5_4723Are phenotypical changes in cells that follow a malignization pathway but are not yet irreversibly malignized.Springer Berlin HeidelbergEncyclopedia of Cancer
Xenobiotic induced proliferation of peroxisomes in hepatic parenchymal cells of rats, mice and several other species is a unique biological phenomenon. Sustained peroxisome proliferation induced in the livers of rats and mice by several structurally unrelated non-mutagenic peroxisome proliferators leads to ...