: existing or occurring prior to the formation of a neoplasm preneoplastic cells Dictionary Entries Near preneoplastic prenatal preneoplastic prenormal See More Nearby Entries Cite this Entry Style “Preneoplastic.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam...
Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the 'Warburg effect' has been widely accepted as a key feature of rapidly proliferating cancer ...
It is the purpose of this review to consider the changes which occur as cells progress from normality to being neoplastic, with particular reference to the cells of the oral mucosa, and the use to which detectable changes can be used as prognostic indicators....
Collectively, these findings support the role of osteopontin in mediating neoplastic transformation of JB6 cells in vitro. In the present study, we hypothesize that induced-OPN stimulates the proliferation and/or prevents anoikis of JB6 ... Hsieh,Yu-Hua,Chang,... - 《Cancer Research》 被引量...
(Pathology) (esp of cells) displaying characteristics that may develop into cancer Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014 ...
Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-尾 family-driven regulation of Sca-1, one of the most commonly used ...
The proliferating fraction increases evenly throughout the liver, but, in all experimental modalities, preneoplastic cells show a proliferative advantage over the phenotypically normal tissue. In each experimental group, the proliferative rate correlates with the pathological evolution. After 2 weeks of ...
Epidermal Growth Factor (EGF), is a potent mitogenic polypeptide that is produced mainly in the salivary glands and the Brunner's gland of the duodenum. It has been demonstrated to be mitogenic, both in vivo and in vitro to a wide variety of epithelial cells including the liver parenchymal ...
To elucidate a possible role of hematogenously transported carcinogens in pathogenesis of peripheral lung carcinoma in humans, we investigated whether the bronchiolar and alveolar epithelial cells of adult human lung xenografts in nude mice could be a target for the chemical carcinogen 4-nitroquinoline-...
The results indicate a partial loss of function in preneoplastic basal cells in cases of dysplasia and carcinoma in situ. In early stages of invasive squamous cell carcinoma of the bronchus, extracellular matrix components obviously could be produced by tumour cells. 展开 ...