We provide examples of preclinical models used to identify and test current therapies for osteoporosis, and discuss common concerns raised when comparing rodent preclinical models to the human skeleton. We focus especially on cortical bone, because it differs between small and larger mammals in its ...
Organoids — Preclinical Models of Human Disease 来自 NCBI 喜欢 0 阅读量: 366 作者: M Li,JC Izpisua Belmonte 摘要: Audio Interview Interview with Dr. Benjamin S. Freedman on organoids as preclinical models of human diseases. (07:11)Download An organoid is a three-dimensional construct ...
The National Institute of Allergy and Infectious Diseases (NIAID) hosted a two-day virtual workshop on leveraging microbial exposure to improve mouse models of human immune status and disease. The workshop's objective was to evaluate the current state of knowledge in the field and to identify ga...
Detailed in this unit are descriptions of two murine models of breast cancer metastasis to bone that can be used to screen the effectiveness of new chemical entities on this disease process. 52:14.18.1‐14.18.23. © 2011 by John Wiley & Sons, Inc. 展开 关键词: breast cancer bone ...
6 Thus, further approaches are required to improve reliability of HER2 testing to ensure that patients receive the appropriate therapy for their individual disease. Although cancer cell lines have proven valuable in the investigation of fundamental cancer research mechanisms, these models have the ...
Mouse models are essential to study and comprehend normal and malignant hematopoiesis. The ideal preclinical model should mimic closely the human malignancy. This means that these mice should recapitulate the clinical behavior of the human diseases such
To improve the therapeutic efficacy, we combined hUC-MSCs with cell sheet technology to evaluate the safety and efficacy of hUC-MSC sheets in preclinical studies using appropriate animal models. Methods hUC-MSC sheets were fabricated by hUC-MSCs from a cell bank established by a standard operation...
An RA model in non-human primate (NHP) is particularly demanded because of the close phylogenesis that provides the cross-re... K Zhang,J Liu,J Deng,... - 《Journal of Immunology》 被引量: 0发表: 2011年 In Vivo Veritas: Preclinical Models of Human Arthritic Disease in Non-Human ...
Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem CellsLu B,Malcuit C,Wang S. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.[J... B Lu,C Malcuit,S ...
Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, Jyotsna Mehta, Seneca E. Fitch, Pandora Pound, Rebecca Ram, Breanne Kincaid, Cathalijn H. C. Leenaars, Minjun Chen, Robe...