Pparg actively represses Nf-kb expression, suggesting that Pparg is likely to be important for inducing the immune cold phenotype in luminal tumors. Fig. 4: K5VP16;Pparg tumors are immune cold. a Immune gene signatures of K5;mTmG control tumors, K5;VP16;Pparg;mTmG mutant tumors, tumors ...
activity, acting in part by antagonizing the nuclear factor-κB (NF-κB) pathway13. Mapping of the mutational landscape of muscle-invasive bladder cancers (MIBCs) together with unsupervised clustering analysis of the whole-genome expression data revealed that MIBC can be sub-categorized into luminal...
brain tissue;2)pioglitazone could improve neurobehavioral and reduce brain edema in rats after TBI;3)the protective effect of pioglitazone was achieved by activating PPARγand reducing NF-kB and IL-6.The neuroprotective effect of pioglitazone on TBI was mediated through the PPARγ/NF-kB/IL-6 ...
NFKB/NF-κB: nuclear factor of kappa light polypeptide gene enhancer in B cells; MTOR: mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid derived 2, like 2; NOX1: NADPH oxidase 1; OPTN: optineurin; PFA: paraformaldehyde; PFU: plaque-forming units; PPARGC1A/PGC-1α...
NFKB/NF-魏B: nuclear factor of kappa light polypeptide gene enhancer in B cells; MTOR: mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid derived 2, like 2; NOX1: NADPH oxidase 1; OPTN: optineurin; PFA: paraformaldehyde; PFU: plaque-forming units; PPARGC1A/PGC-1伪...
Y. (2006). Amelioration of age-related inflammation and oxidative stress by PPARg activator: suppression of NF-kB by 2,4-thiazolidinedione. Experimental Gerontology, 41(6), 590-599.Sung B,Park S,Yu BPet al.Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: ...
YIP EC,LIU AM,WONG JT,et a1.An Aqueous Ex-tract of the Popular Chinese Nutraceutical Kwei Ling Ko(Tortoise shell-Rhizome jelly)Activates the PPARgam-ma Pathway and Down-regulates the NFkappaB Activity. Phytomedicine . 2005E.C.H. Yip,A.M.F. Liu,J.T.Y. Wong,Y.H. Wong.An aqueous ...
PPARg is an E3 ligase that induces the degradation of NFkB/p6512010080604020 0Yongzhong HouFrance MoreauKris ChadeeHou Y, Moreau F & Chadee K 2012 PPARg is an E3 ligase that induces the degradation of NFkB/p65. Nature Communications 3 1300. (doi:10.1038/ ncomms2270)...
We find that these tumors are immune deserted, which may be linked to down-regulation of Nf-kb, a Pparg target. Interestingly, some luminal tumors begin to shift to basal subtype tumors with time, down-regulating Pparg and other luminal markers. Our findings have important implications for ...