The nuclear receptor PPAR[Gamma] is an important regulator of metabolism that forms a heterodimer with RXR to regulate gene transcription. The independent and potential synergistic effects of known agonists for PPAR[Gamma](troglitazone, Tgz) and RXR (LG100268) we...
联合应用PPARγ、RXR激动剂对胃癌SGC7901细胞生长影响及机制探讨影响,探讨RXR,RXRγ,RXRγ、,pparγ,pparα 文档格式: .pdf 文档大小: 1.54M 文档页数: 57页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--毕业论文 文档标签: ...
PPAR_和RXR_的表达上调增强了对肿瘤细胞生长的抑制作用(论文资料),ppar γ,pparα,ppar信号通路,pparγ信号通路,ppar激动剂,ppar research,ppar gamma,pparγ激动剂,pparα激动剂 文档格式: .pdf 文档大小: 346.68K 文档页数: 5页 顶/踩数: 0 / 0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: ...
The nuclear hormone receptors are a large family of transcription factors that bind and respond to a variety of ligands including steroids, retinoids, lipids and haem. One of most extensively studied of these receptors is PPAR-γ gamma (peroxisome proliferator-activated receptor-γ), which forms he...
A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions J Natl Cancer Inst, 92 (2000), pp. 418-423 View in ScopusGoogle Scholar 26 DL Crowe, RA Chandraratna A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is...
Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response elements (PPREs) as the obligate heterodimer with retinoid X receptor (RXR) α, but exactly ho
Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart,...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon,...
PPAR-RXR二聚体与位于启动子或基因内区的过氧化物酶体增殖物反应元件(peroxisome proliferator response elements,PPRE)结合。同时,核受体共激活因子(co-activator)与PPAR-RXR协同作用并且补充和稳同活性转录复合体,可调节脂质代谢,脂肪形成,维持代谢稳态和炎症的基因的表达,并在多种人肿瘤中诱导抗癌作用。
Recent studies performed with null mice suggested a role of either RXR alpha or PPAR gamma in murine placental development. We report here that both PPAR gamma and RXR alpha are strongly expressed in human villous cytotrophoblasts and syncytiotrophoblasts. Moreover, specific ligands for RXRs or...