and PPAR.gamma.. Use of fatty acid coA thioesters, which have been found out as peroxisome proliferator-activated receptors (PPARs) .alpha. and .gamma. inhibitors, in evaluating drugs and utilization thereof in drugs.doi:CA2383140 A1MURAKAMI, KOJI...
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. PPARalpha, beta/delta, and gamma regulate genes involved in the control of lipid metabolism and inflammation and are expressed in all major cell types of a... AC Li,CJ Bi...
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996;15:5336-48.Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, Heyman RA, Briggs M, Deeb S, Staels B & Auwerx J (1996) PPARalpha and PPAR...
Using real-time PCR, Northern, Western, and functional cellular lipid accumulation assays, we show that PPARalpha and PPARgamma activators significantly suppress the expression of apoB-48R mRNA in human THP-1 and blood-borne monocyte-macrophages. Moreover, PPAR activators inhibit the expression of...
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and...
PPAR alpha/gamma dual agonists each target one or more of the key cardiometabolic risk factors of diabetic dyslipidemia, insulin resistance, hyperglycemia, and inflammation; thus, combining their benefits to provide glucose control and ameliorate cardiovascular risks has emerged as an attractive treatment...
已知 PPAR 的三种亚型:PPAR-alpha、PPAR-delta 和 PPAR-gamma。该基因编码的蛋白质是 PPAR-γ,是脂肪细胞分化的调节因子。此外,PPAR-γ 与多种疾病的病理学有关,包括肥胖症、糖尿病、动脉粥样硬化和癌症。已经描述了编码不同亚型的可变剪接转录物变体。[由 RefSeq 提供,2008 年 7 月] 基因ID:5468 产品分类:...
The novel PPAR alpha/gamma dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-kappaB activity. PLoS ONE 2013, 8, e76820. [Google Scholar] Wang, Z.; Coleman, D.J.; Bajaj, G.; Liang, X.; Ganguli-Indra, G.; Indra, A.K. RXRalpha ablation in epidermal ...
In type 2 diabetic patients dual PPAR alpha/gamma stimulation by means of concomitant administration of rosiglitazone and fenofibrate improves the atherogenic dyslipidemic profile of these patients with good tolerability. 展开 关键词: Dual PPAR α/γ stimulation Rosiglitazone Fenofibrate Type 2 diabetes ...
Anti-PPAR gamma antibody - 过氧化酶活化增生受体γ抗体 ￥1098 Anti-PPAR Gamma antibody -过氧化酶活化增生受体γ抗体 ￥1098 Anti-PPAR alpha antibody-α型-过氧化酶活化增生受体单克隆抗体 ￥1580 Anti-PPAR gamma antibody-过氧化酶活化增生受体γ单克隆抗体相关厂家报价产品...