Conclusions Our results showed that PPAR-γ agonist rosiglitazone could inhibit RA-FLS induced osteoclastogenesis and bone resorption activity by down-regulating RANKL expression and suppression of ERK phosphorylation. Funding This work is supported by Chinese National Natural Science Research Grant (no. ...
PPAR敏化剂AIM: Peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma agonists lower lipid accumulation by different mechanisms. We investigated whether benefits could be achieved on insulin sensitivity and lipid metabolism by the dual PPARalpha/gamma agonist chiglitazar in MSG rats. ...
PPAR敏化剂AIM: Peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma agonists lower lipid accumulation by different mechanisms. We investigated whether benefits could be achieved on insulin sensitivity and lipid metabolism by the dual PPARalpha/gamma agonist chiglitazar in MSG rats. ...
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cellsGenisteinC-reactive proteinMatrix metalloproteinase 9Angiotensin IIVascular smooth muscle cells...