Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17, 779–789 (2013). This work uncovers the important role of adiponectin as a downstream effector of FGF21 mediating its metabolic benefits in mice. CAS PubMed Google Scholar...
Ischemic stroke alters myocardial function and cardioprotective pathways: Potential involvement of GDF15 - ScienceDirectBackgroundBoth clinical and experimental data suggest that ischemic stroke deleteriously impacts heart functioning.doi:10.1016/j.acvdsp.2019.02.081A. Méloux...
Finally, the results from our observational study showcase the therapeutic benefits of the triple inhaled BDP/FF/G therapy in COPD, reinforcing the findings of previous randomized controlled trials within a real-world context. Our observational study's results consistently support the therapeutic benefit...
Drug repurposing, often termed drug repositioning, involves re-evaluating existing drugs for new therapeutic uses beyond their original medical indications1. This strategy is promising as it can accelerate the deployment of therapies drastically by bypassing some of the lengthy phases of drug development....
7.1. Multifaceted benefits of ART in liver disease progression ART offers several advantages over conventional drugs due to its multifaceted mechanisms of action and multi-phenotypic modulatory effects. Prevention of HCC is critical, as it is more effective than treatment once the disease progresses. ...
Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the underst
Chronic kidney disease (CKD) is a prevalent worldwide public burden that increasingly compromises overall health as the disease progresses. Two of the most
Hospital costs and benefits of screening for abdominal aortic aneurysms. Results from a Randomised Population Screening Trial. Eur J Vasc Endovasc Surg. 2002;23(1):55–60. 7. Ashton HA, et al. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm ...
(Fig.6g, Supplementary Fig.6a). These findings suggested that 6-MP not only directly targets tumor cells, but also remodels the TME to improve chemotherapy outcomes in FeSighighpatients, indicating combining drug administration with 6-MP may offer significant benefits for FeSighighEGFRWTLUAD ...
The benefits and disadvantages of allogeneic versus autologous cell-based clinical therapies continue to be debated. In a clinical study supported by the National Institutes of Health, this specific question will be addressed by comparing autologous and allogenic MSC therapies in the setting of heart ...