Here, we demonstrate that the circulating hormone Growth and Differentiation Factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, using either heterochronic parabiosis or systemic delivery of recombinant protein, is ...
(D) GDF11 concentration in the serum of female mice underwent sham or OVX surgery for 6 months. **p < 0.01, n = 5. (E–F) GDF11 supplement promotes an aging-induced increase in mRNA and protein levels of FTO in bone marrows of mice in vivo. Mice received daily ...
(E) GDF11 protein levels in sera from young and old rats determined by immunoassay. GDF11 protein content in serum from young (6 months) or old (24 months) rats was measured by immunoassay. Old rats had higher levels of GDF11 compared with young. Data are mean ± SEM (p = 0.0534, ...
In general, PSA levels do not reflect disease status in NEPC because NEPC-derived cancer cells scarcely produce PSA, leading to a difficult challenge in understanding the disease [11]. Hence, in this study, we focused on GDF15, which has been reported to be expressed in NEPC [37, 38], ...
et al. Supraphysiologic administration of GDF11 induces cachexia in part by upregulating GDF15. Cell Rep. 22, 1522–1530 (2018). Article CAS PubMed Google Scholar Lerner, L. et al. Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients. J. ...
7C, D). Furthermore, SLC7A11 and GPX4 protein levels were upregulated with MT supplementation but downregulated after MT2 was blocked with luzindole (P < 0.05) (Fig. 7E–G; full-length blots are presented in Additional file 2: Figures S9–S11). Meanwhile, GDF15 expression was also...
circUCK2 Reduced Neuron Apoptosis via Targeting miR-125b-5p/GDF11 through TGF-b/ Smad3 Signaling (A) Western blot analysis detected the expression of GDF11 protein after circUCK2 inhibitor (circUCK2 siRNA [si-cir- cUCK2]) was added to the HT-22 cell line after OGD tr...
11.根据权利要求10所述的抗体,其中所述效力是10nM或更强。 12.根据权利要求1至11中任一项所述的抗体,所述抗体包含 与所述QUEL‑0201VH结构域SEQ ID NO:12具有至少95%氨基酸序列同一性的VH结构 域,和 与所述QUEL‑0201VL结构域SEQ ID NO:17具有至少95%氨基酸序列同一性的VL结构 域。 13.根据任一项前...
To address this, we isolated the WFIKKN2 FSD and characterized its binding interaction with GDF8 and GDF11. In addition, we solved the crystal structure of the WFIKKN2 FSD to 1.39. The structure revealed conserved, surface exposed, hydrophobic residues that when mutated to alanine reduced full...
Growth differentiation factor 15 (GDF15), which is also commonly called macrophage inhibitory cytokine-1 (MIC-1), is a secreted cytokine of TGF-β superfamily [11,12,13]. Numerous studies have shown that serum GDF15 was significantly increased and correlated with clinical stage, lymphonodus invo...