The protein of hCG is a dimer consisting of an a subunit and a beta subunit. The beta subunit is encoded by the CGB gene and is unique to hCG. Growth differentiation factor-11 (GDF-11), a member of the transforming growth factor-beta ( TGF-beta) superfamily, is expressed in the ...
Growth Differentiation Factor 11 (GDF-11), also known as BMP-11, is a member of the TGF-beta superfamily and is highly related to GDF-8. GDF-11 encodes a 407 amino acid (aa) prepropeptide processed into a 109 aa mature protein. Mature GDF-11 contains the canonical 7-cysteine motif co...
K. The influence of GDF11 on brain fate and function. GeroScience 41, 1–11 (2019). Article PubMed PubMed Central Google Scholar Lau, W. W., Sparks, R., OMiCC Jamboree Working Group & Tsang, J. S. Meta-analysis of crowdsourced data compendia suggests pan-disease transcriptional ...
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These data contained a cluster expressing the interzone marker GDF5 and articular chondrocytes expressing lubricin (PRG4; log fold change = 5.15, P = 4.1 × 10−26) (Fig. 3b and Extended Data Fig. 7d). Notably, FOXP2 (a negative regulator of endochondral ossification) and ...
Follistatin (FST) is a secreted glycoprotein that binds and neutralizes several TGF-beta superfamily proteins including Activin, BMP-6, BMP-7, and GDF-8/Myostatin. It also binds Angiogenin and regulates hematopoietic stem cell adhesion to Fibronectin. Some Follistatin binding partners will also bind...
It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965). Synonyms NOG, noggin, SYM1, SYNS1 Publications SpeciesTitle Cell Stem Cell Increased Neural Progenitor...