1. Differentiated microglia exhibit features of primary cells 分化的小胶质细胞表现出原代细胞的特征 作者首先对人多能干细胞 (hPSC) 刺激分化成microglia-like细胞,然后使用干扰素-β (IFNβ) 刺激模拟病毒样感染的AD microglia。作者在本部分利用scRNA-seq证明hPSC来源的microglia-like细胞与真实患者相一致。 Figure...
LDSC-SEG利用基因表达谱来推断细胞特异性的SNP富集。 RolyPoly(Calderon等人,2017):具有较高GWAS效应大小的变异往往接近在致病组织中表达较高的基因。使用回归模型,RolyPoly 估计细胞类型特异性基因表达对每个组织中 GWAS 效应大小方差的影响。 Prioritizing Causal Genes at GWAS Loci 优先考虑GWAS位点的致病基因【Coloc...
Conclusions We have potentially identified the first genetic risk factor for AD linked to tauopathy.doi:10.1016/j.jalz.2012.05.182Jean-Charles LambertJulien ChapuisPhilippe AmouyelBart DermautElsevier Inc.Alzheimer's and Dementia
Gallagher, M.D. & Chen-Plotkin, A.S. The post-GWAS era: from association to function. Am J Hum Genet 102, 717-730 (2018).Gallagher MD, Chen-Plotkin AS. The Post-GWAS Era: from association to function. Am J Hum Genet 2018;102:717-30....
In this review, I discuss the limitations of GWAS approaches and the major challenges facing geneticists in the post-GWAS era and propose alternative strategies to address these challenges. In particular, I propose that focusing on genetic variations that influences gene expression and using cell ...
With the beginning of the post-GWAS era, more and more studies reveal that, in addition to their value as risk markers, germline variants can exert active roles in prostate oncogenesis. Consequently, current research efforts focus on exploring the biological mechanisms underlying specific ...
, rare or structural variants, presence of different genetic factors in non-european populations, and/or gene-gene and gene-environment interactions. conclusions and future directions in the post-gwas era discoveries in the sequence and structure of the human genome, technical advances in high-...
(mQTLs; also known as meQTLs; Table2), studies oncis-acting genetic–epigenetic interactions are proliferating. Furthermore, such studies are becoming highly relevant as we move into the post-genome sequencing and post-genome-wide-association-study (post-GWAS) era. Mapping of ASM and mQTLs ...
Laying a solid foundation for Manhattan – 'setting the functional basis for the post-GWAS era' 来自 学术范 喜欢 0 阅读量: 60 作者: X Zhang,SD Bailey,M Lupien 展开 摘要: Genome-wide association studies (GWAS) have identified more than 8900 genetic variants, mainly single-nucleotide ...
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era 来自 BioMed Central 喜欢 0 阅读量: 47 作者:WR Swindell,PE Stuart,MK Sarkar…摘要: Background Genome-scale studies of psoriasis have been used to identify genes of potential relevance to disease mechanisms. For many...