Pincus T. Limitations of randomized clinical trials to recognize possible advantages of combination therapies in rheumatic diseases. Semin Arthritis Rheum. 1993;23(2 Suppl1):2-10.Pincus T. Limitations of randomized clinical trials to recognize possible advantages of combination therapies in rheumatic ...
The same author suggested using “algorithms or the combination of multiple markers to mitigate inherent limitations of each marker when used independently”. In a longitudinal cohort study on 38 subjects (men aged 81.3 ± 6 years) affected by AD and followed for an average period of 13 months...
clearly describe the limitations of their methodology for including cases in their analysis: “…although this may inflate the overall accuracy rate (sic)…” [61] (p. 972). However, in both cases, they still proceed to state an accuracy of over 90% for matching premortem group designation...