the suggested routes of SARS-CoV-2 entry into liver cells may be via receptors interaction like 1) ACE2/DDP4 into hepatocytes 2) exaggerated immune responses during the COVID-19 course, and 3) thrombosis in the blood vessels by leading to ischemia/hypoxia and activation of reactive oxygen sp...
Work-up included a regadenoson myocardial perfusion study, which demonstrated patchy apical stress-induced ischemia with an ejection fraction of 30-35%. He was in sinus rhythm throughout the evaluation and never demonstrated persistent tachycardia. Subsequent cardiac magnetic resonance imaging (CMR) was...
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci USA 2013; 110: 20364–20371. 66 Munoz-Pinedo C, Martin SJ. Autosis: a new addition to the cell death Tower of Babel. Cell Death Dis ...
In fact, LVH and elevated left ventricular mass index (LVMI) often precede various outcomes, such as congestive heart failure, cardiac ischemia, arrhythmias, and stroke [21]. Left ventricular hypertrophy is present in up to 85% of children on chronic hemodialysis [17], [22], [23], whereas...
Even though many studies have reported that increased IL-1 release contributes to neurodegeneration in both acute and chronic brain conditions, findings from acute ischemia, stroke and brain injuries show that the release of IL-1 and other pro-inflammatory cytokines, such as TNF-α, may protect ...
Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic hemichannels and gap...
Younger patients, patients with cardiac ischemia and thromboembolic complications, and cerebrovascular problems may all be associated with endothelial dysfunction (Iba et al. 2019). Thromboembolic risk in patients with diabetes mellitus In other studies, other than those related to the unique scenario of...
while at the same time exert beneficial effects on pathophysiologic mechanisms of diabetes-related cardiovascular disease. In the present review, we will present current evidence of the cardiovascular effects of two new classes of antidiabetic medications, glucagon-like peptide 1 (GLP-1) agonists and...
(Higgins et al., 2015), lung-associated heart failure (Dahl et al., 2016), blood vessel compromise (Luo et al., 2017), ischemia-reperfusion (Kirby et al., 2021; Sharma et al., 2018), coagulation (Taylor et al., 2021), and ventilator-associated damage (Jia et al., 2018), ...
cellular homeostasis and to protect hearts against a wide range of heart diseases [1,2]. Interestingly, even acute endurance exercise (3–5 days) provides cardioprotection against an ischemia–reperfusion (I/R) insult, although the molecular mechanisms of exercise-induced cardioprotection remain ...