Cerebral ischemia can lead to destruction of the blood鈥攂rain barrier (BBB), the main cause of cerebral edema and cerebral infarction. BBB damage is also one of the key factors affecting the result of drug therapy. We studied the protective effect of 5-day pretreatment with protocatechuic ...
This video shows an internal simulation of how brainischemiacan lead to a stroke: Ischemiais a formal medical term that’s typically used in the discussion and diagnosis of serious health issues. We kicked off our GI block with sim day! Our PGY...
Disordered calcium homeostasis can lead to endoplasmic reticulum (ER) stress. Our previous data showed that time course activation of ER stress contributes... Y Li,Z Wei,J Tao,... - 《Plos One》 被引量: 94发表: 2012年 Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenua...
Diagnosis is often difficult and requires a thorough clinical history to reveal postprandial pain, early satiety, and nausea and vomiting after eating. Anticipation of these symptoms can lead to a fear of eating with associated food restriction and weight loss. Nonocclusive bowel ischemia is a ...
Regeneration of NAD+by lactate dehydrogenase leads to a similar ~5-fold lactate accumulation in both anoxic turtle and ischemic mouse hearts (Fig.3A). However, in contrast to the ischemic mouse heart, the lactate produced by the anoxic turtle heart can be exported to the circulatory system to...
In off-pump coronary artery bypass surgery, manipulations on the beating heart can lead to transient interruptions of myocardial oxygen supply, which can generate an accumulation of oxygen-dependent metabolites in coronary venous blood. The objective of this study was to evaluate the reliability of in...
Neonatal hypoxia-ischemia encephalopathy (HIE) refers to a brain injury in term infants that can lead to death or lifelong neurological deficits such as cerebral palsy (CP). The pathogenesis of this disease involves multiple cellular and molecular events, notably a neuroinflammatory response driven par...
Background: Myocardial ischemia can lead to fatal ventricular arrhythmias by disrupting the cardiospinal neural network which controls the sympathoexcitati... Siamak Salavatian,Yuki Kuwabara,Benjamin Wong,... - Physiology 被引量: 0发表: 2023年 Associations between female sex hormones, estrous cycle,...
Ischemia commonly impairs the normal regulatory responses of thecerebral circulationand can lead to a state ofvasomotorparalysis, which is manifest by a completely passive blood flow response to changes in perfusion pressure. A major factor thought to impair autoregulatory mechanisms in ischemia is redu...
Special protein 1 (Sp1) is a classical and well-studied transcription factor that can activate target genes by binding to GC-box elements in promoter regions [30,31,32]. Previous studies reported that hypoxia induced Sp1 expression in the nucleus and led to cell injury [33,34]. As predicted...