receptors at low levels in Green monkey kidney (CV1) cells results in a positive transcriptional effect on promoters containing a palindromic thyroid hormone response element, but has a surprisingly negative effect on a thyroid hormone response element derived from the 伪 myosin heavy chain gene. ...
Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures Torsten Lowin, Tareq M. Anssar, Marina Bäuml, Tim Classen, Matthias Schneider & Georg Pongratz Scientific Reports volume 10, Artic...
Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans In this publication we report the identification of a protein likely to be coded by uaY, a regulatory gene in the ascomycete Aspergillus nidulans. uaY is a... Dimitri,Philippides,Claudio,... - 《Molecular...
Through various transplantation studies in mice, we show that CAFs in both invasive lobular breast cancer and triple-negative breast cancer originate from mammary tissue-resident normal fibroblasts (NFs). Single-cell transcriptomics, in vivo and in vitro studies reveal the transition of CD26+ and ...
Structure, evolution, and regulation of a fast skeletal muscle troponin I gene The complete structure of a quail fast skeletal muscle troponin I gene was determined by nucleotide sequence comparison of troponin I genomic and cDNA sequ... Baldwin, A. S,Kittler, E. L,Emerson, C. P - 《Proce...
Thus, if a 2 test battery of Ames and MNvit is used, and gives positive results in the Ames test but negative results in the MNvit, then a second mammalian cell assay (with gene mutation endpoints) should be performed. However, the group noted that bias could result from the small ...
Expression of β-defensin1 gene with its standard errors (SE). DEFB1 expression in secretory tissues of cow mammary gland infected with coagulase-positive or coagulase-negative Staphylococci compared to non-infected samples according to number of lactation; A,B - means differ within parities at p...
Interestingly in two clinical studies, it was observed that HER2-positive tumors responded better to the chemotherapy regimen than HER2-negative tumors [15, 16]. Another study illustrated that cleavage of HER2 mediated apoptosis in cancer cells by inducing intrinsic apoptosis pathway [17]. These stud...
Regulatory T cells play critical roles in the control and modulation of immune responses. Here the authors implicate heterochromatic gene silencing in the susceptibility of CD4+T cell to regulatory T cell suppressive function in a murine allograft model of inflammation. ...
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer is the most prevalent type of breast cancer, in which endocrine therapy resistance and distant relapse remain unmet challenges. Accurate molecular classification is urgently required for guiding pre...