Positive and negative control of virus-induced interferon-A gene expression. Autoimmunity 36 447-455.Mesplède T, Navarro S, Génin P, Morin P, Island ML, Bonnefoy E, Civas A. Positive and negative control of virus-induced interferon-A gene expression. Autoimmunity. 2003; 36 :447–455....
Enhancers are ubiquitous and critical gene-regulatory elements. However, quantitative understanding of the role of DNA looping in the regulation of enhancer action and specificity is limited. We used the Escherichia coli NtrC enhancer-σ54 promoter system as an in vivo model, finding that NtrC activ...
Precise regulation of the transcription factors that control gene expression is vital to accomplish specific tasks as well as to maintain life. Various endogenous and exogenous stimuli induce alterations of the gene expression profiles, and dynamic changes of the profiles are observed in immune ...
In this study, we shed light on the regulation of these surface receptors by cytokines, which play an important role in RA (TNF and IFN-γ) and further provide evidence that SF pre-stimulated with these cytokines differentially influence B cell survival. In addition we investigated the surface...
However, the number of known target genes directly regulated by TRβ1 is limited, and the mechanisms by which positive and especially negative transcriptional regulation occur are not well understood. To characterize the TRβ1 cistrome in vivo, we expressed a biotinylated TRβ1 in hypo- and ...
Evidence for positive and negative regulation of the mouse Cdx2 gene. The caudal family of transcription factors specifies posterior structures during mouse development. We describe the cis-regulatory regions that control mou... WC Wang - 《Journal of Experimental Zoology Part A Comparative Experimental...
This work was extended in 1993 by Raskind et al.5 who showed that the EBV- patients, the acquisition of a Ph chromosome associated with a BCR-ABL1 fusion gene may not be the initial molecular event. induced cell lines were Ph-negative, but of the same G6PD isoenzyme type in 5 of 14...
Many new methods are now available in this Gram-positive species for identifying, manipulating, and studying the regulation of genes involved in spore formation, including the use of transposable genetic elements that create gene fusions in... P Youngman,P Zuber,JB Perkins,... - 《Science》 被...
These results demonstrate the importance of both positive and negative regulatory elements in the regulation of tissue-specific expression of the rat DBH gene.Access through your organization Check access to the full text by signing in through your organization. Access through your organization ...
18.RA has been shown to act as a differentiating agent for both normal and transformed immature myeloid cells,19,20suggesting that thefusion proteinsmight antagonize normal RA-dependent differentiation. Conversely, overexpression of wild type (WT) RARα (as well as dominant negative forms of this ...