405 Circulating Tumors Cells (Ctcs), Positive for Cancer-Stem-Cell (CSC) Markers and Cell-Surface Annexina2, are Significantly Increased in Mice Bearing Metastatic Versus Primary Colon Cancer Tumors Carla Kantara, Shubhashish Sarkar, Carrie A. Maxwell, Robert Ullrich, Pomila Singh...
Cancer-initiating cell (CIC) hypothesis suggests that CICs may be responsible for the generation of tumors that recapitulate the histology of the primary tumor at distant sites. We investigated the distribution of CIC markers (podoplanin (PDPN), CD44, and p63) positive cells of lung squamous cell...
No conventional clinicopathological factors were independently associated with CD44 expression at the invasive tumour front. Conclusions: CD44-positive cancer stem-like cells at the invasive tumour front indicate poor survival and can be a unique biological prognostic factor for GC....
& Luo, Q. Prognostic and therapeutic significance of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in early and midstage colorectal cancer first-line chemotherapy. Comput. Math. Methods Med. 2021, 2294562. https://doi.org/10.1155/2021/2294562 (2021). ...
This prompted us to investigate the relationships between obesity and the presence of breast cancer markers. Hence, the purpose of this study is to pave a way for development of a blood based gene expression test for early detection of breast cancer in obese premenopausal women. We have ...
markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local therapy. Although the normal ranges reported have differed by institution, the positivity of tumor markers is consistent and can easily be assessed. Kumamoto and Wakayama’s group clearly ...
Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your personal data. Manage preferences for further information and to change your choices....
Reliability and Variability of Ki-67 Digital Image Analysis Methods for Clinical Diagnostics in Breast Cancer 2024, Laboratory Investigation Citation Excerpt : Additionally, the Ki-67 labeling index used in conjunction with established breast histopathologic markers may serve as a feasible and cost-effecti...
Patients were evaluated for any sign of tumor progression or adverse event every 2 months in addition to radiologic assessments. An increase in tumor serum markers alone could not define a progression. Secondary end points were OS from the time of randomization, PFS in subgroup analyses (by ...
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug — the monoclonal antibody trastuzumab — almost 25 years ago....