View bio Learn about positive feedback loops. Study the negative, natural, and positive feedback loop definitions with examples, and identify their importance in science. Updated: 11/21/2023 Table of Contents Positive Feedback Loop Definition Positive Feedback Loop Examples How to Identify a Posi...
et al. A positive feedback loop controls Toxoplasma chronic differentiation. Nat Microbiol 8, 889–904 (2023). https://doi.org/10.1038/s41564-023-01358-2 Download citation Received26 April 2022 Accepted07 March 2023 Published20 April 2023 Issue DateMay 2023 DOIhttps://doi.org/10.1038/s41564...
through activating caspase-3. In addition, we found that miR-16-5p can inhibit EV71 replication. CCNE1 and CCND1, two important cell cycle regulators, play an important role in the suppression of EV71 replication by miR-16-5p. Therefore, miR-16-5p is a positive feedback regulator in EV71...
By stimulating the JAK2/STAT3-C/EBPβ-IL6 pathway, IL-6 can promote the release of additional IL-6, creating a positive feedback loop in TAMs; thus, it promotes EMT, invasion, and migration of lung cancer in vivo and in vitro. In contrast, TAM-induced lung cancer metastases were ...
6N). These above results indicate that circ-YAP was transcriptionally activated by YAP, thus forming a positive feedback loop promoting CRC liver metastasis. Fig. 6 Circ-YAP is transcriptionally activated by YAP. A, B. qRT-PCR analysis of total and nascent circ-YAP levels in YAP-silenced or...
In summary, we reveal a positive feedback loop between the leukemia-initiating fusion protein AML1-ETO and the m6A demethylase FTO in t(8;21) AML. AML1-ETO upregulates the expression of FTO through PU.1; FTO in turn promotes the expression of AML1-ETO by inhibiting YTHDF2-mediated AML...
This positive feedback loop may be the underlying mechanism by which activating the VTA-BLA-NAc circuit rescues the reward insensitivity induced by chronic stress (Fig. 7A-D). In conclusion, we uncovered a novel positive feedback loop, the VTA-BLA-NAc circuit, that is activated by positive ...
Mechanistically, IMPDH1 and YB-1 formed an autoregulatory positive feedback loop: IMPDH1 maintained YB-1 protein stabilization; YB-1 induced IMPDH1 expression by binding to the IMPDH1 promoter motif. Functionally, IMPDH1-assembled cytoophidia physically interacted with YB-1 and translocated YB-1 ...
2) Mouse studies have revealed that a sustained increase in plasma CXCL12 mediates pain chronicity through the positive feedback loop of CXCL12/CXCR4 axis, thereby enhancing the plasticity of spinal pain synapses. 3) SNI induced a dramatic inflammatory immune response in damaged nerve stump and ...
feedback information from emotional changes. Thus, an ACCGlu–VTAGABA–VTADA–ACCGlupositive-feedback loop mediates the progression to and maintenance of persistent pain and comorbid anxiodepressive-like behavior. Disruption of this feedback loop relieves hyperalgesia and anxiodepressive-like behavior in...