So far, polyunsaturated fatty acids and their biologically active derivatives have been shown to regulate cell survival, neurogenesis, brain inflammation and synaptic function. Altered fatty acid signalling has been implicated in mood disorders, cognition, Alzheimer's disease, schizophrenia and other condit...
polyunsaturated fatty acidshighly unsaturated fatty acidsNAD+ recyclingThe reactions catalyzed by the delta-5 and delta-6 desaturases (D5D/D6D), key enzymes responsible for highly unsaturated fatty acid (HUFA) synthesis, regenerate NAD+ from NADH. Here, we show that D5D/D6D provide a mechanism...
Materials and Methods: Immortalized mouse Schwann (IMS32) cells were incubated with the ω-3 PUFAs docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The mRNA levels of several antioxidant enzymes [heme oxygenase-1 (Ho-1), NAD(P)H quinone oxidoreductase 1 (Nqo1), catalase (Cat),...
Potential role of brain-derived neurotrophic factor in omega-3 Fatty Acid supplementation to prevent posttraumatic distress after accidental injury: an open-label pilot study. Psychother Psychosom. 2011;80:310–2. PubMed Google Scholar Vines A, Delattre AM, Lima MM, Rodrigues LS, Suchecki D, ...
Eicosapentaenoic acid HATs: Histone acetyltransferases HDACs: Histone deacetylases HMGB1: High mobile group box 1 IFN: Interferon IL: Interleukin MAPK: Mitogen-activated protein kinase mNSS: Modified neurological severity scores NAD: Nicotinamide adenine dinucleotide NF-κB: Nuclear factor-κB...
Modified neurological severity scores NAD: Nicotinamide adenine dinucleotide NF-κB: Nuclear factor-κB RAGE: Receptor for advanced glycation end products TBI: Traumatic brain injury TLRs: Toll-like receptors TNF: Tumor necrosis factor ω-3 PUFA: Omega-3 polyunsaturated fatty acid ...
Prostaglandins Leukot Essent Fatty Acids 2016. Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A et al. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology 2015...
The fatty acid composition of neuronal membranes influ- ences cellular function through direct effects on membrane biophysical properties, but also by providing a precursor pool for signalling molecules and lipid-derived media- tors [1]. N-6 and n-3 LCPUFA are the precursors to a vast array ...
Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis. Int Immunol. 2019;31:559–67. Article CAS PubMed Google Scholar Bazinet RP, Metherel AH, Chen CT, Shaikh SR, Nadjar A, Joffre C, et al. Brain eicosapentaenoic acid metabolism as a lead for novel ...
Both DSC and Laurdan results suggest little effects of the free fatty acids on phospholipid bilayers in the fluid, or liquid-crystalline form. Furthermore Laurdan, but not DSC, can be conveniently used to assess the fatty acid effects on a fluid bilayer, such as one composed of pure egg PC...