This chapter focuses on a specific category of polymers that have been evaluated in various strategies of targeted delivery of different types of nucleic acids; however, due to conspicuous role of delivery systems in cancer therapy as well as tissue regeneration, the presented data is mainly ...
Nucleic acids transfer into mammalian cells requires devices to improve their escape from endocytic vesicles where they are mainly confined following cellular uptake. In this review, we describe histidine-rich molecules that enable the transfer of plasmid and oligonucleotides (ODN) in human and non-hum...
CPPs utilized for dsRNA delivery are distinguished by their abundance of basic residues, particularly lysine and arginine, facilitating interactions with the anionic nucleic acids (dsRNA) via ionic bonds76. Among these, polyarginine and protamine are the most extensively studied for pest control. ...
Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method. 展开 ...
renowned for their ability to traverse the plasma membrane75. CPPs utilized for dsRNA delivery are distinguished by their abundance of basic residues, particularly lysine and arginine, facilitating interactions with the anionic nucleic acids (dsRNA) via ionic bonds76. Among these, polyarginine and pro...
Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines. Drug Discov. Today 26, 1891–1903 (2021). Article Google Scholar Lee, H., Jeong, J. H. & Park, T. G. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low ...
Recent interest in clinical therapy has been directed to deliver nucleic acids (DNA, RNA or short-chain oligonucleotides) that alter gene expression within a specific cell population, thereby manipulating cellular processes and responses, which in turn stimulate immune responses or tissue regeneration, ...
Analysis of nucleic acids and proteins in capillary electrophoresis and micro- chip capillary electrophoresis using polymers as additives of the background electrolytes. Current Analytical Chemistry 2006; 2: 17- 33.Hsieh M. M,Chiu T. C,Tseng W. L. et al.Analysis of nucleic acids and proteins ...
Proteins, nucleic acids, polysaccharides, rubber and lignin, inorganic po... EA Macgregor,CT Greenwood - 《Polymers in Nature》 被引量: 116发表: 1980年 Bioengineering, thermal physiology and comfort | Clc Natural high polymers, extraction and purification, size and shapes of molecules. Proteins, ...
Sequence-specific binding polymers for duplex nucleic acids A polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide containing different Watson-Crick basepair oreientaions. The composition includes an uncharged backbone with 5- or 6-me.....