Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.D·H·维基菲尔德N·罗西D·B·罗泽玛L·埃尔米达
The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges histidine-rich domains, which include peptides, polyethylenimine, polysaccharides, platform delivery systems, viral phages, mesoporous silica particles, and ... J He,S Xu,AJ Mixson - 《Pharmaceutics》 被引量:...
Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method. 展开 ...
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The invention provides methods for using an electron microscope to sequence by direct inspection of labeled, stretched nucleic acid, such as DNA. The methods, devices, and compositions of the invention allow controllable placement of a nucleic acid on a substrate, so that there is consistent base...
Sequence-specific binding polymers for duplex nucleic acids A polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide containing different Watson-Crick basepair oreientaions. The composition includes an uncharged backbone with 5- or 6-me.....
Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Onaca, Ozana,Enea, Ramona,Hughes, David W.,Meier, Wolfgang. Macromolecular ... O Onaca,R Enea,DW Hughes,... - 《Macromolecular Bioscience》 被引量: 0发表: 2009年 Intelligent nucleic acid delivery systems based on sti...
To develop these advanced materials, biomaterials are often functionalized with ligands for cell attachment or protein binding. However, many ligands lack specificity of recognizing their targets or their binding functions are difficult to control. In this chapter, nucleic acid aptamers are introduced ...
A novel nucleic acid fluorescent sensing platform based on nanostructured films of intrinsically conducting polymers. When fluorophores attach to nanostructured films of intrinsically conducting polymers (ICPs), a quenching of their fluorescence may occur. We have exploite... - 《Analytica Chimica Acta》...
Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications Gene therapy promises to treat diseases that arise Kauffman,C Amy,Piotrowski-Daspit,... - 《Biomacromolecules》 被引量: 0发表: 2018年 Poly(urea ester): A family of biode...