Polyamide polymers containing defined oligo (alkylene amino) acids, methods for their production, their use as a delivery reagent for nucleic acids, pharmaceutical compositions containing said polyamide polymers, and uses thereof are provided.The, Designation of The Inventor Has Not Yet Been Filed...
Nucleic acids transfer into mammalian cells requires devices to improve their escape from endocytic vesicles where they are mainly confined following cellular uptake. In this review, we describe histidine-rich molecules that enable the transfer of plasmid and oligonucleotides (ODN) in human and non-hum...
α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery. Adv. Drug Deliv. Rev. 171, 139–163 (2021). Article Google Scholar Zhu, R. et al. Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI). ...
Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method. 展开 ...
MEANS FOR DELIVERY OF NUCLEIC ACIDS ACTIVE FOR GENE SILENCING USING SYNTHETIC POLYMERSThe invention relates to a composition useful as transfection agent, comprising polyamines modified by aromatic amino acids and small double-strand or single-strand RNA active for RNA interference.Abdennajj Adib...
Sequence-specific binding polymers for duplex nucleic acids A polymer composition effective to bind in a sequence-specific manner to a target sequence of a duplex polynucleotide containing different Watson-Crick basepair oreientaions. The composition includes an uncharged backbone with 5- or 6-me.....
摘要:A survey is given on recent work in the authors' laboratorites dealing with the preparation and application of functional polymers, which are to be used (a) as supports for nucleic acid synthesis and (b) as carriers mediating the interaction of the immobilized nucleic acid chains with dis...
Specifically we dealt with the activity of the two major class of biological macromolecules, proteins and nucleic acids. We addressed such questions as: (1) how does the base sequence in a region of DNA influence its three-dimensional structure especially in ways that might facilitate the ...
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Recent interest in clinical therapy has been directed to deliver nucleic acids (DNA, RNA or short-chain oligonucleotides) that alter gene expression within a specific cell population, thereby manipulating cellular processes and responses, which in turn stimulate immune responses or tissue regeneration, ...