The preparation and properties of vinyl polymers carrying the bases of nucleic acids as substituents are described. These compounds form specific complexes with complementary polynucleotides, a process which prevents the latter from functioning as templates in the synthesis of polymeric nucleic acid or ...
d) Amino acids are the monomers of proteins. e) Deoxy What term correctly describes the monomeric subunit that is linked together to form the nucleic acid polymer? What are monomers of DNA and RNA composed of, and what is the difference between...
Polymeric materials have been extensively used in biomedical engineering applications in the form of surgical tools, implantable devices and coatings, catheters, vascular grafts, injectable materials, and tissue engineering scaffolds. Natural polymers, such as collagen (from biological tissues), chitosan (...
Depending on the intracellular site of action, they may play an important role in cytosolic migration, nuclear import, and subsequent presentation of the nucleic acid in active form. Ideally, polymers act in a bioresponsive way to overcome the different delivery steps. Therapeutic developments with ...
Precipitaion of nucleic acid and cation polymer at acidic ph; adjustment of ph to release nucleic aciddoi:EP0707077 B1Nucleic acids can be made available for amplification or other treatment after lysis by contacting the lysate with specific weakly basic polymers to form a precipitate with the ...
A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanopar...
Thermoplastic polymersor thermosoftening plastics are the other type of synthetic polymers. While thermoset plastics are rigid, thermoplastic polymers are solid when cool, but are pliable and can be molded above a certain temperature. While thermoset plastics form irreversible chemical bonds when cured,...
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in large qua... E Wagner,J Kloeckner - Springer Berlin Heidelberg 被引量: 199发表: 2006年 Isozyme, Randomly Amplified Polymorphic DNA (RAPD), and Restri...
Many natural and synthetic polycations have been used for delivery of nucleic acids, with the focus mostly on DNA delivery until the potential of siRNA became apparent. These include histones (H1, H3, or H4), polylysine, histidylated polylysine, polyornithine, polyarginine, high-mobility group ...
Polymers make up many of the materials in living organisms, including, for example, proteins, cellulose, and nucleic acids. Moreover, they constitute the basis of such minerals as diamond, quartz, and feldspar and such man-made materials as concrete, glass, paper, plastics, and rubbers. The ...