Autosomal Dominant Polycystic Kidney Disease in Older Adultsdoi:10.25259/ijn_561_23MORTALITY risk factorsRISK assessmentPOLYCYSTIC kidney diseaseMEDICAL screeningCOMORBIDITYDISEASE progressionWu, Henry H. L.Wood, GrahameChinnadurai, RajkumarIndian Journal of Nephrology...
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The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. The PKD1 protein, polycystin-1, is a large receptor-like protein, whereas polycystin-2 is a transient receptor potential channel. ...
to sixth decade of life.1 The disease occurs in approximately 1:800 to 1:1,000 people and accounts for 2.5% of all cases of end-stage renal disease.1,2 Clinically, ADPKD presents over the course of decades with hypertension, flank pain, hematuria, and renal cyst infections in adults. Cy...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited disorders in humans. It is the most frequent genetic cause of renal failure in adults, accounting for 6-8% of patients on dialysis in the United States. ...
2 Polycystic kidney disease occurring in adults is distinguished from the infantile form. The latter is inherited as an autosomal recessive gene; is far less common; is characterized by cysts occurring primarily in the collecting ducts, rather than all along the tubule; and is usually fatal in ...
Autosomal-dominant polycystic kidney disease: tolvaptan use in adolescents and young adults with rapid progressionThe phase 3 Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO 3:4) clinical trial demonstrated the beneficial effect of ...
Adults with autosomal dominant polycystic kidney disease (ADPKD) and PKD1 mutations have a more severe disease than do patients with PKD2 mutations. The aim of this study was to compare phenotypes between children with mutations in the PKD1 / PKD2 genes. Fifty PKD1 children and ten PKD2 children...
On the other hand, hereditary polycystic disease is a frequent cause of CKD in children and adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are the best known cystic ... M Meola,I Petrucci,C Ronco - 《Contributions to Nephrol...
Genes responsible for autosomal dominant polycystic kidney disease are PKD-1 and PKD-2, which express polycystin-1 and -2, respectively. Isolated polycystic liver disease has been linked to two genes, PRKCSH and SEC63, which express hepatocystin and SEC63p, respectively. The gene respo...