Background: Prior studies suggest that the presence of >5% polyclonal plasma cells (pPCs) among total plasma cells (PCs) within the bone marrow (BM) is associated with a longer progression-free survival, higher response rates, and lower frequency of high-risk cytogenetic abnormalities in ...
The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute ...
Bence Jones proteins in the urine consisted of type K and type L. The myeloma cells aspirated from the bone marrow were composed of two cell types on light- and electronmicroscopic observation; the one had chromatin-rich nucleus with a prominent nucleolus and parallel endoplasmic reticula, the ...
characterized by clonal proliferation of mature plasma cells in the bone marrow, with small numbers of these cells observed in the peripheral blood.1The prevalence is estimated to be 3.2 per 100,000 individuals greater than 50 years of age; increasing in prevalence with...
a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple ...
The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of ...
The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute ...
The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute ...
in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of establishment of protein localization to plasma membrane negative regulation of release of ...
Eleven patients with plasma cell dyscrasias underwent high-dose chemoradiotherapy and anti-B-cell monoclonal antibody (MoAb)-treated autologous bone marrow... KC Anderson,BA Barut,J Ritz,... - 《Blood》 被引量: 810发表: 1991年 Visualization of the vesicular acetylcholine transporter in cholinergic...