Elkon R, Ugalde AP, Agami R (2013) Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet 14:496-506Elkon, R., Ugalde, A.P. and Agami, R. (2013) Alternative cleavage and poly- adenylation: extent, regulation and function. Nat. Rev. Genet. 14, 496- ...
the maturation of messenger RNA precursors (pre-mRNAs), involving the processing of 3’termini, is critical for mRNA function and stability [1]. In the processing of the 3’termini, the 3’end of nascent mRNA is cleaved, followed by addition of a poly(A) tail (i.e., polyadenylation). ...
Alternative cleavage and polyadenylation: extent, regulation and function. Nat. Rev. Genet. 14, 496-506.Elkon, R., A.P. Ugalde, and R. Agami, ... E Ran,AP Ugalde,R Agami 被引量: 0发表: 2017年 Alternative isoform regulation in human tissue transcriptomes. PolyadenylationAlternative Splicing...
(UTRs), thereby potentially regulating the function, stability, localization and translation efficiency of target RNAs. Here, we review our current understanding of the polyadenylation process and the latest progress in the identification of APA events, mechanisms that regulate poly(A) site selection,...
Alternative cleavage and polyadenylation: extent, regulation and function. The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and polyadenylated. Recent discoveries have revealed that a large proportion o... Elkon,Ran,Ugalde,... - 《Nature Reviews Genetics》 被引量:...
with the partial disruption of the β1-strand (R1266E_β1-GS) resulted in a ~20% decrease in the termination efficiency of Sen1 (Extended Data Fig.10b,c). The limited effect of these mutants on the Sen1 termination activity could be because of the intact RNA-binding function of Sen1...
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We have constructed 14 independent point mutations in the conserved AAUAAA element of the SV40 late polyadenylation signal in order to study the recognition and function of alternative polyadenylation signals. A variant RNA containing an AUUAAA was polyadenylated at 20% the level of wild-type substr...
Our finding clearly contradicts the notion that the poly(A) tail has any function in encapsidation and viral reverse transcription. 展开 关键词: transcripcion inversa transcription inverse reverse transcription DOI: 10.1083/jcb.200803094 被引量: 28 ...
mRNAs are subject to capping at the 5’ end and polyadenylation at the 3’ end, which are essential molecular elements for the proper function of mRNA. RNA Processing By 1974, mRNA from a variety of eukaryotic species and viruses were found to be methylated A significant amount of this ...