Boston Biochem, in partnership IQ Proteomics, offers its AQUA services for the characterization and quantification of poly-Ubiquitin chains on your protein.
上海玉博生物科技有限公司 主要致力于“Poly-ubiquitin chains (Ub2-7) (K48-linked) BML-UW8860-0100”的生产销售。多年的“Poly-ubiquitin chains (Ub2-7) (K48-linked) BML-UW8860-0100”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称
This complex post‐translational modification system is under intense investigation, but generation of specific Ub chains and tools made thereof is not always trivial. We discovered that native methionine‐1‐linked polymeric ubiquitin chains can be constructed in a single chemical reaction. We validate...
Modification of proteins by addition of K63-linked polyubiquitin chains is implicated in a variety of cellular events, including DNA repair, signal transduction and receptor endocytosis. A monoclonal antibody (mAb) has been generated that specifically recognizes K63-linked polyubiquitin chains, but not...
Ub itself has seven Lys residues (K6, K11, K27, K29, K33, K48, and K63), each of which can participate in further ubiquitylation, generating poly-Ub chains. The ability of Ub to form polymers through various lysines as well as the NH2-terminus appears to be central to the ...
2b). To ascertain how these interactions may affect UBE2R2 activity, various mutant UBE2R2 proteins were assayed for the neddylated CRL-dependent formation of unanchored poly-ubiquitin chains33,38 (Extended Data Fig. 3e). In brief, UBE2R2 is first thioesterified to radio-labeled donor ...
Binding of K63-linked poly-ubiquitin chains to the H abc domain may regulate the function of syntaxins in membrane fusion or may suggest additional functions of this protein family.doi:10.1101/219642Adrian J. GiovannoneElena RealesPallavi Bhattaram...
The RNA sensor MDA5 recruits the signaling adaptor MAVS to initiate type I interferon signaling and downstream antiviral responses, a process that requires K63-linked polyubiquitin chains. Here, we examined the mechanisms whereby K63-polyUb chain regulate MDA5 activation. Only long unanchored K63-...
(LTN1) modifies the truncated polypeptide with K48-linked ubiquitin chains to target it for degradation in a p97-dependent manner through the proteasome [3,6,7]. Whereas peptide release and ribosome recycling by the RQC complex are relatively well understood, less is known about the mechanisms...
上海玉博生物科技有限公司 主要致力于“Poly-ubiquitin chains (Ub2-16) (K48-linked) BML-UW0670-0100”的生产销售。多年的“Poly-ubiquitin chains (Ub2-16) (K48-linked) BML-UW0670-0100”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名