Takahashi Y, Strunnikov A (2008) In vivo modeling of polysumoylation uncovers targeting of topoisomerase II to the nucleolus via optimal level of SUMO modification. Chromosoma 117: 189-198Takahashi Y., Strunnikov A. In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II ...
1.To find out the physiological function in cell growth,differentiation or apoptosis of poly-SUMOylation will be important.与单SUMO化修饰不同的是,多聚SUMO化修饰的靶蛋白可以进一步被泛素化修饰,进而诱导靶蛋白的降解。 英文短句/例句 1.Characterization of Protein Poly-SUMOylation Modification蛋白质多聚...
然后,采用组合突变产生了eIF5A1突变体,并在体外评估了它们的SUMOylation(图2B),结果表明SUMO可以在体外结合到eIF5A1的不同残基上。 体内实验中,作者在蛋白酶体抑制剂MG132存在的情况下进行了SUMOylation实验(图2C)。与WT蛋白相比,这两种突变体的SUMOylation明显减少(图2D)。而且,与WT蛋白相比,eIF5A1-3KA和eI...
10. Marmor-Kollet, H. et al. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell 80, 876-891 e876 (2020). 11. Markmiller, S. et al. Context-Dependent and Disease-Specific Diversity in Protein ...
SUMOylation, the process of covalently conjugating small ubiquitin-like modifiers (SUMOs), is required for both the formation and the disruption of PML-NBs. However, detailed mechanisms of how SUMOylation regulates these processes remain unknown. Here we report that SUMO5, a novel SUMO variant,...
Medical Encyclopedia Wikipedia AcronymDefinition PDSMPolydimethylsiloxane(silicone) PDSMProject Design Standards Manual(Woodmoor Improvement Association; Monument, CO) PDSMProduct Data Systems Modernization(USAF) PDSMPower Dragon Scale Mail PDSMphosphorylation-dependent sumoylation motif ...
Abstract Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based nuclear structures that regulate various cellular processes. SUMOylation, the process of covalently conjugating small ubiquitin-like modifiers (SUMOs), is required for both the formation and the disruption of PML-NBs. However, deta...
Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells J. Cereb. Blood Flow Metab., 27 (2007), pp. 950-962 CrossrefGoogle Scholar [39] I. Ginis, J.M. Hallenbeck, J. Liu, ...
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase Nat. Chem. Biol., 15 (2019), pp. 276-284 CrossrefView in ScopusGoogle Scholar 53 M. Fottner, M. Weyh, S. Gaussmann, D. Schwarz, M. Sattler, K. Lang A modular toolbox to generate complex polymeric ...
Mitotic and meiotic functions for the SUMOylation Pathway in the Caenorhabditis elegans germline. Genetics 208, 1421–1441 (2018). Article CAS PubMed PubMed Central Google Scholar Mateo, A. R. et al. The p53-like protein CEP-1 is required for meiotic fidelity in C. elegans. Curr. Biol...