[医学]deSUMOylation - 脱SUMO化修饰;去SUMO化修饰(热度:1380) SUMO是一种小泛素相关修饰物,参与蛋白质的翻译后修饰,这一修饰过程即称为SUMO化。SUMO化修饰在加强蛋白质的稳定性、核质转运、DNA的修复和复制、染色体的有丝分裂、减数分裂等调节细胞活动中发挥重要作用。SUMO化是一动态过程,能被SUMO特异性蛋白酶(...
SUMOylated Kaiso can activate transcription from exogenous methylated promoters, wherein the deSUMOylated form of the protein kept the ability to be a repressor. Rapid Kaiso deSUMOylation occurs in response to hyperosmotic stress and is reversible upon return to an isotonic environment. DeSUMOylatio...
SUMO (Small Ubiquitin-like Modifier) is a ubiquitin-like protein that can covalently modify a large number of cellular proteins. SUMOylation is a dynamic proces...
1.To find out the physiological function in cell growth,differentiation or apoptosis of poly-SUMOylation will be important.与单SUMO化修饰不同的是,多聚SUMO化修饰的靶蛋白可以进一步被泛素化修饰,进而诱导靶蛋白的降解。 6)SUMO enzymesSUMO酶 1.We intitule the progress that the small ubiquitin-related...
SENP3 is a redox-sensitive de-SUMOylation protease that plays an important role in macrophage function . However, doubt remains on whether SENP3 and SUMOylation regulate macrophage ferroptosis. For the first time, the results of our study suggest that SENP3 sensitizes macrophages to RSL3-...
3.抑制SUMOylation通过下调miR-130b上调GR来提高Dex的敏感性 有报道称GR的表达是Dex反应的主要机制,并与MM患者较好的预后有关。研究发现GR表达与原代MM细胞Dex IC50s值呈负相关 (图3A)。基于SUMOylation抑制增强了Dex的敏感性,进而评估抑制SUMOylation...
Wrestling with stress: Roles of protein SUMOylation and deSUMOylation in cell stress response. IUBMB Life. 2014; 66 :71–77. doi: 10.1002/iub.1244... CG And,JM Henley - 《Iubmb Life》 被引量: 56发表: 2014年 SUMOylation and PPARgamma: wrestling with inflammatory signaling. The molecula...
Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting p
In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).关键词:...
TNF-induced nuclear transport of SENP1 correlates with de-SUMOylation of HIPK1 (homeodomain-interacting protein kinase 1) and cytoplasmic translocation of HIPK1, leading to an increase in ASK-1 (apoptosis signal-regulating kinase 1)-dependent apoptosis. Thus, it is clear that SENP1 can enhance...