Influence of Hydroxylation and Copper Binding on Poly (L-Proline) Type II Helix Formation in the N-terminal Domain of the Prion ProteinA family of neurodegenerative disorders including scrapie, chronic wasting disease, bovine spongiform encephalopathy and Creutzfeldt-Jakob disease are thought to be ...
mutations may induce a conformational change in the carboxy terminal helix, which distorts correct orientation of the poly(L-proline) binding residues. But as judged from the CD-spectra and modeling experiments, this structural change is probably very subtle (Figure2). In addition, mutations may ...
Moreover, “ΔV for the coil-helix transition [of poly-L-glutamic acid, PLGA] is in the order of 1 ml. per amino acid residue” [54]; such an extremely small value of ∆V¯tr is surprisingly comparable to that of galacturonan, in spite of the large structural difference of the...
The UBE2R2 catalytic UBC domain also recruits the acceptor ubiquitin through residues located on both the N-terminal portion of α-helix3 and its preceding loop in a unique manner (Fig. 3a). This differs from a UBE2R2 acceptor ubiquitin binding surface recently proposed52. The placement of ...
Myeloproliferative disorders (MPD) constitute a subset of hematological malignancies characterized by a stem cell-originated clonal proliferation of aberrant myeloid cells, one of which is polycythemia vera (PV). PV is the most common myeloproliferative disorder with an annual incidence of at least 23 ...
Based on the helix propensity scale, positively charged amino acids (K/R) have a tendency to form α-helices (Pace and Scholtz, 1998). Since PBMs are located in lysine- and arginine-rich regions, it would be likely to find several of them in a helical conformation. A summary of pADPr...
Therefore, it is expected that the high-molecular-weight poly(L-valine) does not take an extended conformation like the /3-sheet type, but rather an a-helix or similar helical structure. Including the present polypeptide, the a-axis dim- ensions of the unit cells in a-polypeptides are ...
小鼠多瘤病毒抗体(英文简写:POLY-Ab)北京血清检测为体外检测的科学研究用产品,不能用于临床诊断,盒子内的试剂不能用于注射,口服或者其他临床用途。 CⅠCP ELISA试剂盒英文名:Sheep Interleukin-2 receptor,IL-2R ELISA Kit ELISA操作须知:试剂应妥善保存于4℃冰箱内,在使用时先平衡至室温,不同批号的试剂组分不宜...
Approaches to utilize the ectodomains of single membrane-spanning type I cytokine receptors such as the TNF or IL-6 receptor have been successfully developed as immunomodulatory drugs7, 41. However, mimicking the ectodomain of seven-helix membrane-spanning GPCRs is inherently complex due to the ...
Still further, triple helix molecules can be utilized in reducing the level of target gene activity. These techniques are described in detail by L. G. Davis, et al., eds, Basic Methods in Molecular Biology, 2nd ed., Appleton & Lange, Norwalk, Conn. 1994. In another alternative, the ...