Definition noun A long stretch of (about ten to 200 or more) adenine nucleotides added to the “tail” or 3′ end of the pre-mRNA via the process called polyadenylation catalyzed by the enzyme, polyadenylate polymerase (PAP). Supplement In eukaryotic organisms, most messenger RNA molecules end...
Looking for online definition of Poly(A) tail in the Medical Dictionary? Poly(A) tail explanation free. What is Poly(A) tail? Meaning of Poly(A) tail medical term. What does Poly(A) tail mean?
The poly-A tail is a long chain of adenines nucleotides that is added to a messenger RNA (mRNA) molecule during RNA processing to increase the stability of the mRNA molecule
3 processing is an essential step in the maturation of all messenger RNAs (mRNAs) and is a tightly coupled two-step reaction: endonucleolytic cleavage at the poly(A) site is followed by the addition of a poly(A) tail, except for metazoan histone mRNAs, which are cleaved but not polyaden...
Poly(A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in the oocyte-to-embryo transition (OET). Nothing is known about poly(A) tail dynamics during the human OET. Here, we show that poly(A) tail length and internal non-A residues are highly dynamic during the hu...
Paul D.Ray,Rebecca C.Fry, inSystems Biology in Toxicology and Environmental Health, 2015 Polyadenylation Polyadenylationof the 3′ end occurs before themRNAleaves the nucleus. This polyadenylate tail, around 100–200 nucleotides long, protects the mRNA from the degradatory action of phosphatases and...
1.3).317 All mRNA except those encoding most histone proteins have poly(A) tails. The length of the poly(A) tail that added ranges from 200 to 250 bp and is quite uniform among eukaryotic organisms. Once the transcript reaches the cytoplasm, the length of the poly(A) sequence decreases ...
While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating maternal RNA poly(A) tail length are not fully understood. In this study, we identified MARTRE, a previously uncharacterized protein family (MARTRE1-MARTRE6...
Emsley for advice; the MRC Laboratory of Molecular Biology Electron Microscopy Facility for access and support of electron microscopy, sample preparation and data collection; Diamond for access and support of the Cryo-EM facilities at the UK national Electron Bio-Imaging Centre (eBIC) (proposal no....
Using a Drosophila melanogaster cell-free translation system, we found that this effect is mediated by the poly(A)-binding protein (PABP). miRNA repression was positively correlated with poly(A) tail length, but this stimulatory effect on repression was lost when translation was repressed by the...