2023年6月8日,美国斯坦福大学Aaron D. Gitler研究组与贝勒医学院Steven Boeynaems研究组合作在Molecular Cell发文题为Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates,发现Poly(A)结合蛋白PABPC与神经退行性疾病相关的应激颗粒蛋白Ataxin-2通过一个14个氨基酸短序列相互作作用...
Definition Poly (Adenin)‐binding protein ( PABP ) is a multifunctional binding protein that plays an important role in mRNA stability and protein translation. PABP is found complexed to the 3‐prime poly(A) tail of eukaryotic mRNA , and is required for poly(A) shortening and translation. ...
在分子水平上,卵母细胞中不能有效建立起母源mRNA储备,生成的mRNA由于poly(A)尾长度短于正常范围而不稳定,半衰期变短,翻译能力降低;而且由于不能向nuclear poly(A) domain中有效募集CPSF蛋白,使mRNA的3ʹ-UTR剪切存在异常,改变了转...
Definition Nuclear poly(A) binding protein 1 (PABPN1) designates a protein that binds to the growing poly(A) tails of mRNA precursors during nuclear processing. The protein is required for efficient poly(A) synthesis, and for limiting the length of the poly(A) tail in a mammalian cell to...
英文名称:Rabbit anti-human poly(A) binding protein, cytoplasmic 4 (inducible form) polyclonal Antibody [poly(A) binding protein, cytoplasmic 4],中文名称:兔抗人poly(A)结合蛋白,细胞质4(诱导型)多克隆抗体[poly(A)结合蛋白,细胞质4],产品货号:MBS713116
Eukaryotic mRNA has a cap structure and a poly(A) tail at the 5′ and 3′ ends, respectively. The cap structure is recognized by eIF (eukaryotic translation initiation factor) 4 F, while the poly(A) tail is bound by poly(A)-binding protein (PABP). PAB
Although SG protein composition differs depending on the stressful condition, the yeast main poly(A) binding protein Pab1 represents a specific component, commonly used as a SG marker in its GFP-tagged form22,26. Moreover, Pab1 regulates many other aspects of the mRNA metabolism through its ...
翻译起始复合物通过eIF4G与细胞质poly(A)-binding protein (PABPCs)的相互作用进一步稳定,后者识别3 ' poly(A)尾部,形成多聚体复合物和闭环结构。PABPCs具有双重作用,通过与eif结合启动翻译,并通过掩盖poly(A)尾部以防止死乙烯化来延...
We identified the “poly(A)-binding protein-interacting protein 2” (PAIP2) as a new VEGF mRNA 3′-UTR interacting protein. By RNA electromobility shift assays, we showed that PAIP2 binds to two distinct regions of a domain encompassing base 1 to 1280 of the VEGF 3′-UTR. Such in ...
Abstract. In testis mRNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). Here we have cloned a n