Changing prognosis in paroxysmal nocturnal haemoglobinuria disease subcategories: an analysis of the International PNH Registry. Intern Med J. 2016; 46(9):1044-53. https://doi.org/10.1111/imj.13160 PMID: 27305361.
The prognosis of PNH can be poor in many cases, so a timely and accurate diagnosis — in addition to appropriate treatment — is critical to improving patient outcomes. About ULTOMIRIS® ULTOMIRIS® (ravulizumab-cwvz) is the first ...
“It can take months, and sometimes years, to receive a correct diagnosis for PNH — a chronic, progressive and potentially life-threatening rare disease – which can be an overwhelming experience for children and their famil...
Finding a better prognosis among patients with AA before diagnosis of PNH might be surprising, we thus reassessed, the differences between the AA-PNH syndrome and de novo PNH. Age, gender and symptom distributions were similar in both groups, at diagnosis. However, when comparing these patients ...
Evolutions to AA or malignant disease (MD) were related to poor prognosis in 2 of the 3 groups (Classical PNH and AA-PNH for AA; AA-PNH and Unclassified PNH for MD). We also found a protective role of the treatment in the AA-PNH group [RR without treatment 3.1 (95% CI 1.5–6.5)...
PrognosisEculizumabParoxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with substantial risk to develop thromboembolic events. We analyzed diagnostic and ...
Finding a better prognosis among patients with AA before diagnosis of PNH might be surprising, we thus reassessed, the differences between the AA-PNH syndrome and de novo PNH. Age,gender and symptom distributions were similar in both groups, at diagnosis. However, when comparing these patients ...
According to our data, it is not concluded that the parameters tested are associated with disease prognosis or VTE recurrence. In certain populations, a higher percentage of minor clone(s) was observed; re-examination and systematic follow-up might be useful for specific individuals cases. Further...