Changing prognosis in paroxysmal nocturnal haemoglobinuria disease subcategories: an analysis of the International PNH Registry. Intern Med J. 2016; 46(9):1044-53. https://doi.org/10.1111/imj.13160 PMID: 27305361.
Opinion. Discusses the epidemiological reviews by Gerard Socie and his associates in France that are in the August 31, 1996 edition of 'The Lancet.' Reviews' confirmation that paroxysmal nocturnal haemoglobinuria (PNH) is a disease that knows no age limits; Finding that onset at a later age ...
PrognosisEculizumabParoxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with substantial risk to develop thromboembolic events. We analyzed diagnostic and ...
Evolutions to AA or malignant disease (MD) were related to poor prognosis in 2 of the 3 groups (Classical PNH and AA-PNH for AA; AA-PNH and Unclassified PNH for MD). We also found a protective role of the treatment in the AA-PNH group [RR without treatment 3.1 (95% CI 1.5–6.5)...
Finding a better prognosis among patients with AA before diagnosis of PNH might be surprising, we thus reassessed, the differences between the AA-PNH syndrome and de novo PNH. Age, gender and symptom distributions were similar in both groups, at diagnosis. However, when comparing these patients ...
Finding a better prognosis among patients with AA before diagnosis of PNH might be surprising, we thus reassessed, the differences between the AA-PNH syndrome and de novo PNH. Age,gender and symptom distributions were similar in both groups, at diagnosis. However, when comparing these patients ...