7cells.Theseresultssuggestthatsilibininrepresentsapotentialanti-metastaticagentsuppressingPMA-inducedcancercellinvasion throughthespecificinhibitionofAP-1-dependentMMP-9geneexpression. Ó2006ElsevierInc.Allrightsreserved. Keywords:Silibinin;Milkthistle;MCF-7humanbreastcarcinomacells;Invasion;PMA;MMP-9 Invasionand...
The human monocyte-like cell line, U937, also synthesizes C2 and can be stimulated to increase this synthesis by lymphokine-rich culture supernates. Additionally, phorbol myristate acetate (PMA), an agent which induces maturational changes in other macrophage-like cell lines, also stimulates C2 ...
Therefore, CBD is a potential pharmacological agent to treat coronary artery disease, myocarditis, and pulmonary hypertension [[11], [12], [13]]. However, currently, no CBD formulations are available to treat cardiovascular disorders in clinical settings, and the precise mechanisms underlying CBD-...
The latter belong to a monocytic differentiation lineage derived from malignant cells of a patient with generalised histiocytic lymphoma [31], and their differentiation with PMA, a potent tumour promoting agent [32], is known to impart functional properties typical of macrophages [32–34]. The ...
Sylgard 184 polydimethylsiloxane (PDMS) prepolymer and curing agent were obtained from Ellsworth Adhesives (Germantown, WI, USA). 2.2. Cell Culture and Preparation RAW 264.7 macrophages were cultured in DMEM plus supplements and maintained in polystyrene culture flasks as previously described in detail ...