备注:载体使用Stbl3、Stbl4或Stable感受态细胞进行转化和扩增,可以减少载体基因重组几率。 载体介绍 pLP1 (Proteolipid Protein 1) is a Protein Coding gene. Diseases associated with PLP1 include pelizaeus-merzbacher disease and spastic paraplegia 2, x-linked. Among its related pathways are Glial Cell Diffe...
PLP1 (Proteolipid Protein 1) is a Protein Coding gene. Diseases associated with PLP1 include pelizaeus-merzbacher disease and spastic paraplegia 2, x-linked. Among its related pathways are Glial Cell Differentiation and SIDS Susceptibility Pathways. GO annotations related to this gene include structur...
佩梅病(Pelizaeus-Merzbacher disease, PMD)是一种严重的、X染色体连锁的、髓鞘形成异常与神经功能障碍的脑白质病变,该疾病是由蛋白脂蛋白PLP1(Proteolipid protein 1)突变引起的【1,2】。PLP1的点突变和多拷贝变异会导致严重和致命的疾病。PLP1-null的病...
To investigate the role of the ASE in vivo, the element was deleted from the native gene in mouse using a Cre/lox strategy. Although removal of the ASE from Plp1-lacZ constructs profoundly decreased expression in transfected oligodendroglial cell lines (N20.1 and Oli-neu), the element was ...
integrin-mediated signaling pathway chemical synaptic transmission axon ensheathment positive regulation of gene expression astrocyte development substantia nigra development central nervous system myelination long-chain fatty acid biosynthetic process cell maturation axon development glial cell differentiation ...
FOXG1 syndrome; neurodevelopmental disorder; mouse model; proteolipid protein 1 (PLP1); gene therapy; antisense oligonucleotides (ASOs)1. Introduction FOXG1 syndrome is a rare neuro-developmental disorder (≈3 in 100,000 births [1]) for which there is currently no treatment or cure. Patients ...
How does the activation of Satellite Glial Cells (SGCs) influence the expression of Calcitonin Gene Related Peptide (CGRP)? What role do Satellite Glial Cells (SGCs) play in mechanical hypersensitivity? What is the significance of the proximity of Satellite Glial Cells (SGCs) to pain-sensing ...
pLP1 (Proteolipid Protein 1) is a Protein Coding gene. Diseases associated with PLP1 include pelizaeus-merzbacher disease and spastic paraplegia 2, x-linked. Among its related pathways are Glial Cell Differentiation and SIDS Susceptibility Pathways. GO annotations related to this gene include structur...