Poly lactic-co-glycolic acid (PLGA) is a biodegradable polymer with good biocompatibility. Because the products of its hydrolysis process are Lactic acid (LA) and Glycolic acid (GA), the middle products of normal metabolism, which are finally catabolized into carbon dioxide and wa...
Because the products of its hydrolysis process are Lactic acid (... 彭巧,宋宁,马巍,... - 《Progress in Modern Biomedicine》 被引量: 0发表: 2015年 载抗肿瘤药物PLGA微球的研究 重要因素.影响这两个过程的工艺参数很多,如乳化剂的浓度,油相聚合物浓度,药材比,乳化油水相体积比和乳化速度等.本文研究...
Several mechanisms rule drug release process from PLGA MPs: polymer degradation, water absorption, drug diffusion into PLGA matrix, erosion, and hydrolysis. The degradation process of the polymer regulates the drug release from PLGA MPs so it is important to understand this mechanism and by which p...
The introduction of functionality across the polymer side-chain allowsa wide variety of strategies to prepare PAOx-based hydrogels.36,37Lecommandoux et al. introduced reactive amine units along the PEtOxchain by partial hydrolysis. The obtained PEtOx–PEI copolymers weresubsequently crosslinked with a...
In this sense, the expression of vacuolar type H+-ATPase (ATP6V0A1), a crucially important enzyme that acidifies lysosomal compartment and may facilitate PLGA hydrolysis, was highly correlated with LDHB and co-expressed only in GIT. Together, these data suggest that efficient PLGA degradation ...
α-tricalcium phosphate hydrolysis; poly(lactide-co-glycolide); biodegradable polymer; bone composite Abstract The microstructural and mechanical properties of composites composed of calcium deficient hydroxyapatite (CDHAp) and poly(lactide-co-glycolide) (PLGA) have been investigated. The composites were fo...
Generally speaking, polymers containing free -COOH groups are more hydrophilic (Wan & Yang, Citation2016), and ester-terminated PLGA has better hydrolysis resistance than acid-terminated PLGA, and the degradation cycle becomes longer (Kim et al., Citation2019; Wang et al., Citation2019). In ...
molecular weight PLGA polymers due to higher hydrolysis and degradation rates. It is foreseeable that the encapsulation of active pharmaceutical ingredients in PLA/PLGA biopolymers by nano spray drying will continue to increase as laboratory equipment becomes more widespread. In particular, nano spray ...
Hydrolysis was performed at 56 degrees C-a temperature slightly above the glass transition of the polymers. The effects of polymer chemistry, composite formation technique, and porosity on hydrolysis kinetics and degree of transformation were examined with isothermal calorimetry, X-ray diffraction (XRD)...
However, whether using polylactic acid (PLA), polyglycolic acid (PGLA or PGA) or polylactic acid/polyglycolic acid co-polymer (PLA/PGLA or PLA/PGA or PGLA), depends on the desired bioavailability, as well on the mechanical properties, the in vivo hydrolysis rate and the clearance rate of ...