PAOx allow for highly defined polymerstructure and composition enabling fine tuning of the hydrophilic–hydrophobicbalance of the polymer by copolymerization and, thus, the control on micellesize and drug release properties. Most reported PAOx-based micellar systems featurea hybrid PAOx-polyester (PAOx-P...
Since no external solvent phase is used, it is suitable for most drug molecules whether they are hydrophilic or hydrophobic (Bee et al., Citation2018). Figure 5. Schematic of the electrospray process for preparing PLGA microspheres. Display full size Figure 6. Schematic diagram of the spray ...
Due to their high biocompatibility and excellent properties (high surface/volume ratio, tunable physical and chemical features, versatile functional surfaces that allow the binding of hydrophilic or hydrophobic compounds, and easy functionalization), poly(. dl-lactic acid) and poly(lactic-co-glycolic ...
Depending on the PLGA concentration, the particles either formed a core-shell or a composite microparticle structure. The microparticles facilitate the simultaneous incorporation of both hydrophobic and hydrophilic molecules, due to their amphiphilic macromolecule composition. Further, due to the lower ...
1.Synthesis methods of poly(ethylene glycol)-poly(lactic acid) copolymers(PEG-PLA) with block or star structures and their terminated derivatives,including their applications in loading hydrophilic,hydrophobic or protein drugs in forms of micelle,microparticle,hydrogel and vesicle are summaried.本文综述...
to produce a partially hydrophilic/hydrophobic microfluidic device by adding a surfactant to PDMS solutions before curing (Chong et al.2015; Montazeri et al.2016). Particularly, they added to PDMS a super spreading biodegradable non-ionic surfactant, Silwet L-77®that is able to improve the ...
(4):1485-1495.THOTEAJ,CHAPPELLJT.Reductionintheinitial-burstreleasebysurfacecrosslinkingofPLGAmicroparticlescontaininghydrophilicorhydrophobicdrugs[J].DrugDevIndPharm,2005,31(1):43-57WISCHKEC,ZHANGY,MITTALS,etal.DevelopmentofPLGAbasedinjectabledeliverysystemsforhydrophobicfenretinide[J].PharmRes,2010,27(10...
that can be delivered and released in a controlled way in the body. Encapsulation essentially offers protection to an API from enzymatic or acidic degradation in the stomach, improves diffusion of the drug across the digestive tract, and offers a way of introducing hydrophobic molecules into the ...
1C), a widely used steric stabilizer [29] or using a mixture of PVA and Poloxamer-407 (P407), namely P-F and PP-F respectively. The P407 is an ABA-type triblock copolymer with a centre block of hydrophobic polypropylene oxide (PPO) in between two hydrophilic polyethylene oxide (PEO) ...
From these reasons, hydrophilic siRNA and Fab′ needed to be covalently linked to hydrophobic PLGA, respectively. In addition, this mixed micelle system can change the mixing ratio within a certain range compared with a single polymer molecule whose mixing ratio of siRNA and Fab′ cannot be ...