More than four decades after their first approval, platinum drugs still stand among the most widely utilized anti-cancer agents1. Nowadays, almost 50% of cancer patients receiving chemotherapy (CT) are indeed treated with systemic platinum-based regimen1,2. Notwithstanding platinum drugs’ effectivenes...
Platinum-based chemotherapy drugs are a type of chemotherapy that uses platinum compounds to treat cancer. These drugs work by damaging the DNA in cancer cells, preventing them from replicating and causing the tumor to shrink. Examples of these drugs include cisplatin, carboplatin, and oxaliplatin....
Platinum-baseddrugs,suchascisplatin,arean importantclassofthe mostactivechemotherapeuticagentsthat arewidely usedtoOS. 以铂类为基础的药物,例如顺铂,是骨肉瘤化疗常用的有效的药物。 www.fabiao.net 4. Cisplatinandotherplatinum-basedcancerdrugsdestroytumorcellsbybindingtoDNAstrands,interferingwithDNAreplication. ...
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs. This ...
eIF3a gene polymorphism and chemo-sensitivity to platinum-based drugs in ovarian cancer 来自 Semantic Scholar 喜欢 0 阅读量: 100 作者:C Zhang,S Zhang,Y Liu,T Yan,Z Yu 摘要: Objective: To investigate the relationship between the eukaryotic initiation factor 3a(e IF3a)polymorphisms and chemo-...
platinum-based drugsleaving group of carboplatinoxaliplatintrans-diamminedichloroplatinumDNA–protein ternary cross-linkspolynuclear platinum compoundsplatinum(IV) complexesphotoactive Pt(IV) azide complexesIntroduction, Anti-tumor Activity of CisplatinAnti-tumor Activity of Carboplatin, Oxaliplatin and Nedaplatin...
求翻译:drugs, most prominent of these being the platinum-based是什么意思?待解决 悬赏分:1 - 离问题结束还有 drugs, most prominent of these being the platinum-based问题补充:匿名 2013-05-23 12:21:38 药物,最突出的被铂类为基础的 匿名 2013-05-23 12:23:18 药物,是最突出的这些基于白金的...
Platinum-based anticancer agents have been in widespread use for many years to successfully treat many different types of cancer. However, the efficacy of these drugs is limited by serious side effects. One of the strategies to reduce the side effects is encapsulation of the drug in a lipid ...
which developed resistance towards MAPKi show an enhanced susceptibility to platinum-based drugs, such as cisplatin and carboplatin. We found that this enhanced susceptibility inversely correlates with the expression level of the p53 family member TAp73. We show that the lower expression of the TAp73...
Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs. S. Komeda, "Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs," Metallomics, vol. 3, no. 7, pp. 650-655, ... Seiji,Komeda - 《Metallomics Integrated Biometal ...