Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S, Schreibelt G, de Boer A, Van Herpen CM, Kaanders JH, Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest. 2011....
Platinum-based drugs (cisplatin, carboplatin, and oxaliplatin) are widely used therapeutic agents for cancer treatment. Even though the platinum (Pt)-drugs are routinely used clinically, a clear picture of their distribution within tumor tissues is lacking. The current methods to image the ...
Platinum-based anticancer agents have been in widespread use for many years to successfully treat many different types of cancer. However, the efficacy of these drugs is limited by serious side effects. One of the strategies to reduce the side effects is encapsulation of the drug in a lipid ...
platinum-based drugsleaving group of carboplatinoxaliplatintrans-diamminedichloroplatinumDNA–protein ternary cross-linkspolynuclear platinum compoundsplatinum(IV) complexesphotoactive Pt(IV) azide complexesIntroduction, Anti-tumor Activity of CisplatinAnti-tumor Activity of Carboplatin, Oxaliplatin and Nedaplatin...
Numerous platinum-based drugs have been synthesized over the years, but only a few of them have been clinically approved. Among these, cisplatin has enjoyed the most success and is used either alone or in combinatorial therapy. Cisplatin was first used for the treatment of cancer in humans in...
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs. This ...
Platinum-based chemotherapy drugs are a type of chemotherapy that uses platinum compounds to treat cancer. These drugs work by damaging the DNA in cancer cells, preventing them from replicating and causing the tumor to shrink. Examples of these drugs include cisplatin, carboplatin, and oxaliplatin....
Platinum-baseddrugs,suchascisplatin,arean importantclassofthe mostactivechemotherapeuticagentsthat arewidely usedtoOS. 以铂类为基础的药物,例如顺铂,是骨肉瘤化疗常用的有效的药物。 www.fabiao.net 4. Cisplatinandotherplatinum-basedcancerdrugsdestroytumorcellsbybindingtoDNAstrands,interferingwithDNAreplication. ...
More than four decades after their first approval, platinum drugs still stand among the most widely utilized anti-cancer agents1. Nowadays, almost 50% of cancer patients receiving chemotherapy (CT) are indeed treated with systemic platinum-based regimen1,2. Notwithstanding platinum drugs’ effectivenes...
which developed resistance towards MAPKi show an enhanced susceptibility to platinum-based drugs, such as cisplatin and carboplatin. We found that this enhanced susceptibility inversely correlates with the expression level of the p53 family member TAp73. We show that the lower expression of the TAp73...