Method Ten patients who had experienced immediate hypersensitivity reactions due to platinum-based chemotherapy drugs, 10 patients who were known to tolerate these agents and 5 healthy controls were included in the study as the patient group, the patient-control group and the healthy control group, ...
Platinum-Based Chemotherapy: A Vital Tool in Cancer Treatment May 29, 2023 Platinum-based chemotherapy drugs are a type of chemotherapy that uses platinum compounds to treat cancer.See also Iridium's impact The story of iridium is both modern and prehistoric. It was discovered along with osmium ...
The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 2018;47(19):6645–6653. doi:10.1039/C8DT00838H 155. Waissbluth S, Daniel SJ. Cisplatin-induced ototoxicity: transporters playing a role in cisplatin toxicity. Hearing Research. 2013;299:37–45. ...
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs. This ...
Combining Immunotherapy and Chemotherapy for Non Small Cell Lung Cancer Over the past year, the combination of platinum-based chemotherapy and immunotherapy has become the standard of care for patients with metastatic non-small... JBH Judd - 《Thoracic Surgery Clinics》 被引量: 0发表: 2020年 A ...
Drug resistance is a major obstacle for platinum based chemotherapy, and one of the most common reasons is GSH-mediated detoxification. To overcome this problem, we proposed ethacrynic acid (EA), a GST inhibitor, to reduce the conjugation of GSH with platinum agents so as to sensitize cancer...
Cisplatinandotherplatinum-basedcancerdrugsdestroytumorcellsbybindingtoDNAstrands,interferingwithDNAreplication. 顺铂和其他以铂为基础的癌症药物通过靶定DNA链,干扰DNA复制而破坏肿瘤细胞。 article.yeeyan.org 5. Thepatientshadallreceivedthreecyclesofplatinum-basedchemotherapy. ...
Confirmation of a direct role for GSTP1 in chemotherapy response is important, not only in the prediction of response to platinum-based chemotherapy, but as a candidate response biomarker for new generation chemotherapy drugs, designed to exploit increased GSTP1 expression in tumours relative to ...
Methods: Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDITOF MS) analysis was performed to detect 57 cases of e IF3 a polymorphic genotypes(rs3824830, rs77382849, rs10787899 and rs3740556) after platinum-based chemotherapy drugs up to 6 cycles in primary ovarian ...
Polymorphisms in the XRCC1 gene are associated with treatment response to platinum chemotherapy in advanced non-small cell lung cancer patients based on meta-analysis. Association of Base Excision Repair Gene Polymorphisms with the Response to Chemotherapy in Advanced Non-Small Cell Lung Cancer Because...