By systematically analyzing 648 samples regarding platinum drug response from the Cancer Genome Atlas (TCGA), we have identified 32 dysregulated lncRNAs across 11 cancer types that could affect platinum-based chemotherapy response, of which 78.125% (25/32) were significantly down-regulated in drug-...
as your first treatment when your lung cancer has spread to other parts of the body (metastatic), or in combination with pemetrexed and platinum-based chemotherapy, as your first treatment when your lung cancer has spread to nearby tissues (locally advanced) or to other parts of the body (me...
KEYTRUDA, in combination with fluoropyrimidine- and platinum-containing chemotherapy, is indicated for the first-line treatment of adults with locally advanced unresectable or metastatic HER2-negative gastric or gastroesophageal j...
was observed. The TMB cutpoints associated with improved survival varied markedly between cancer types. These data indicate that TMB is associated with improved survival in patients receiving ICI across a wide variety of cancer types, but that there may not be one universal definition of high TMB...
chemotherapy, or radiation therapy, as well as combinations of these treatments. Targeted therapies and immunotherapy treatments are becoming more common, as well. The decision about which treatments will be appropriate for a given individual must take into account the location and extent of the tumor...
KEYTRUDA, in combination with pemetrexed and platinum chemotherapy, is indicated for the first-line treatment of patients with metastatic nonsquamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations. KEYTRUDA, in combin...
Advances in multimodality therapy have included the use of a class of chemotherapy drugs referred to as folate antimetabolites. The most common drug used in this class is pemetrexed, which is most effective when combined with platinum-based agents, such as cisplatinum. These drugs may be given ...
has spread to other parts of the body, and has been previously treated with chemotherapy that contains platinum. It is not known if GILOTRIF is safe and effective in children. IMPORTANT SAFETY INFORMATION Before you take GILOTRIF, tell your healthcare provider if you: ...
chemotherapy, or radiation therapy, as well as combinations of these treatments. Targeted therapies and immunotherapy treatments are becoming more common, as well. The decision about which treatments will be appropriate for a given individual must take into account the location and extent of the tumor...
Chemotherapy is a common, effective treatment for mesothelioma. Learn more about when it's used and what to expect.