Clemetson KJ, Polga´r J: Platelet adhesion and aggregation receptors, in Bruchhausen FV, Walter U (eds): Handbook of Experimen- tal Pharmacology, vol 126, Platelets and Their Factors. Berlin, Ger- many, Springer-Verlag, 1997, p 155...
cytosolic portion of the activated GPIIb/IIIa complex binds to the plateletcytoskeletonand can mediate platelet spreading andclot retraction.Ligand bindingto the integrin GPIIb/IIIa-mediatesplatelet adhesionand aggregation, and triggers what is referred to as ‘outside-in’ signaling, resulting in ...
Effects on Platelet Aggregation and Adhesion,TXAand PGIof Plasma of Fufangdanshenfang in Normal Rabbits复方丹参方血小板聚集性和粘附性血栓素A2前列腺素I2采用半体内实验方法,观察了复方丹参方对正常家兔血浆血小板聚集性,粘附性及TXA,PGI的影响.结果表明:正常家兔口服复方丹参方1.2,2.4,4.8g/kg及Aspirin 4.4mg...
Regulation of platelet adhesion and aggregationThe present invention relates to methods for regulating platelet adhesion and aggregation in a subject. The methods involve administration of analogues or antagonists of thrombospondin-1 (TSP-1).Philip John Hogg...
As outlined in this review, the roles of platelets extend beyond initial platelet adhesion and aggregation at the site of injury. Platelets are not ‘merely’ contributing to processes such as coagulation, inflammation, and antimicrobial responses or wound healing, they are arguably central and essent...
in which the viral entry into host cells is mediated by the ACE2 receptor, causing vascular endothelial damage and resulting in endothelial vascular dysfunction and vasculitis (i.e., the inflammation of blood vessels)2,6. Since VWF is a factor that mediates platelet adhesion and aggregation at ...
The effects of activation of plasminogen by streptokinase and tissue- type-plasminogen activator on platelet activation and the membrane glycoproteins (GPs) that mediate platelet adhesion and aggregation are not yet fully defined. To clarify effects on platelets during activation of plasminogen in vitro...
Nitric oxide (NO) inhibits platelet adhesion and aggregation in vitro. In vivo, chronic inhibition of NO synthesis induces nephrosclerosis and hypertension. Although the pathophysiological mechanism of this glomerular injury has not been clarified, sympathetic nerve activation, a potent procoagulant stimulus...