However, in contrast to the predictions of the model, the time-course of the scattering intensity changes during platelet aggregation was characterized by single exponential decay with a rate constant which reached a limiting value of 0.017 s 1 at high platelet concentrations. The value of k agg...
INTRAVASCULAR injection of adenosine diphosphate (ADP) in several species including man 1 and rabbit 2 induces platelet clumping with concomitant fall in circulating platelet count. It is well established that following vascular injury white thrombi form at the site of insult 3 . The first stage ...
So further investigations on the mechanism of anti-platelet aggregation are necessary to discover a new type of anti-platelet drugs,such as antagonists of the EP3 receptor.关键词: anti-platelet aggregation drugs mechanism review 被引量: 7
However, the precise molecular mechanism of shear stress-induced platelet aggregation (SIPA) has yet to be clarified.Page %P Close Plain text Look Inside Citations Other actions Reprints and Permissions Export citation About this Book Add to Papers Share Share this content on Facebook ...
P. The growing complexity of platelet aggregation. Blood 109, 5087–5095 (2007). Article CAS PubMed Google Scholar Sharma, U. et al. Structural basis of homo- and heterotrimerization of collagen I. Nat. Commun. 8, 14671 (2017). Article ADS PubMed PubMed Central Google Scholar Park, ...
Human placental circulation maintaining mechanism-platelet aggregation inhibiting activity of human placental chorioepithelial brush border membrane : H. Iioka, S. Akada, H. Hisanaga, I. S. Moriyama & M. Ichijo (Department of Obstetrics and Gynecology, Nara Medical University, Shijocho 840, Kashihara...
Platelets play a critical role in the pathogenesis of atherothrombotic processes and inhibition of platelet aggregation by antiplatelet therapy is essential and really important in the acute coronary syndromes or in the setting of percutaneous coronary intervention. The first family of adenosine diphosphate...
Figure 1 Structure of ADAMTS13 Figure 1 Mechanisms of platelet adhesion and aggregation Patients With Severe Aortic Valve Stenosis and Impaired Platelet Function Benefit From Preoperative Desmopressin Infusion Barbara Steinlechner, MD, Petra. The Role of Endothelial Cell Injury in Thrombotic Microangiopath...
Alternatively, coenzyme Q10 may increase the synthesis and sensitivity of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation, to arterial smooth muscle and does relaxation to arteries [104]. Effect of Co-Q10 on cardiac dysfunction Clinically, Co-Q10 has potential for ...
Therefore, in this review, we mainly focus on discussing the pharmacological mechanism of action (MoA) of Dantonic® for the treatment of CSA, including the promotion of coronary microcirculation, the optimization of myocardial energy metabolism, and the inhibition of platelet aggregation. Graphical ...