plasma p-tau in paired samples from neurochemically defined biomarker-positive AD vs. biomarker-negative controls in cohort 1. A, B Boxplots of the concentrations of p-tau231 and p-tau181 in serum and plasma respectively. C The diagnostic performance of p-tau231 and p-tau181 in the paire...
Albumin, a type of protein that is soluble in water and in water half saturated with a salt such as ammonium sulfate. Serum albumin is a component of blood serum; α-lactalbumin is found in milk. Ovalbumin constitutes about 50 percent of the proteins of
In recent years, blood-based biomarkers (BBB) from plasma and serum are showing promise for the diagnosis of AD [3, 4]. BBB can potentially be used by both specialized and primary care clinics to test the heterogenous older population at risk for AD and may represent a valuable screening ...
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia. Neurology. 2016;87(13):1329-1336.PubMedGoogle ScholarCrossref 16. Shaw LM, Vanderstichele H, Knapik-Czajka M, et al; Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid biomarker ...
A serum neutralization titer of 1:80 is approximately equivalent to a titer of 1:1280 for S-RBD–specific IgG. To ensure the therapeutic potency of the convalescent plasma, only the plasma units with an S-RBD–specific IgG titer of at least 1:640 were used for this study. Additional ...
(version 1.3, downloaded on 2018-05-14) database to identify what effect the variants are predicted to have on the function of the gene-product. CADD incorporates many different types of annotations and is widely used. From the CADD database, we used the PHRED-scaled CADD scores, meaning ...
rest of the studied miRNAs as indicated by higher heritability estimates (mean: 0.12 for 63 miRNAs vs mean: 0.08 for 2083 miRNAs). Of these 63 miRNAs, 47 miRNAs were among the well-expressed miRNAs in plasma (Methods), meaning that we could measure these miRNAs reasonably better than the ...
Human IgG subclasses in maternal and fetal serum. Vox Sang 21, 481–492 (1971). 42. Bladergroen, M. R. et al. Automation of High-Throughput Mass Spectrometry-Based Plasma N-Glycome Analysis with Linkage- Specific Sialic Acid Esterification. J. Proteome Res. 14, 4080–4086 (2015). 43....
High antibody titer was defined in this meta-analysis as S-protein receptor-binding domain–specific IgG antibody titer of 1:640 or higher or serum neutralization titer of 1:40 or higher. For each outcome, we collected either the number of events for the convalescent plasma and control groups...
34 Plasma homocitrulline reflects the carbamylation rate of serum proteins, promotes autoimmune and inflammatory responses,35-38 and may be associated with neuroinflammation39 and proteinopathy.35,40-42 Homocitrulline also promotes endothelial dysfunction and vascular disease,43 possibly indicating a ...