(1973). Relationship between plasma or serum drug concentration and amount of drug in the body at steady state upon multiple dosing. I Pharmacokin. Biopharm , 1 , 17–22D. Perrier and M. Gibaldi. Relationship between plasma or serum concentration and amount of drug in the body at steady ...
Human serum was dried in this department at the outbreak of war with a view to its possible use as a stable substitute for whole blood for transfusion purposes. In the absence of any definite knowledge of dosage, the arbitrary unit of 200 c. c. was chosen, because this was approximately ...
Clustering of cells per subpopulation revealed a drastic difference between the uninfected and infected cells (Fig. 3b–d and Supplementary Movies 2 and 3). Uninfected cells, which had infected neighbors, formed a separate cluster at 9 and 12 hpi (arrowhead in Fig. 3c). However, only the ...
Neutrophils are the most abundant leukocyte in humans and provide a critical early line of defense as part of our innate immune system. We perform a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell...
This noticed difference was not, how- those with low and normal C-peptide levels, the difference ever, statistically significant (p = 0.11). was not statistically significant (p = 0.45) (Figure 13). Serum C-peptide level and the age of the patients The patients were classified into 3 ...
Although the larger particles had the lowest dissolution rate, it is assumed that this effect is only due to the changed surface-to-volume ratio, because the difference between larger and smaller particles was not nearly as significant as expected. Experimental challenges analyzing complex matrices ...
Light-chain amyloidosis (AL) results from misfolding of light-chains secreted by clonal plasma cells 2, 3, which involves the heart in 50% to 75% of cases (4). Once believed to be untreatable, contemporary therapies have improved survival for AL 5, 6. ATTR-CM is increasingly being ...
Malaria is a major parasitic disease of humans and is a health public problem that affects more than 100 countries. In 2017, it caused nearly half a million deaths out of 219 million infections. Malaria is caused by the protozoan parasites of the genus P
Plasma and CSF KP were associated with decreases in ReHo in the basal ganglia and dorsomedial prefrontal regions (DMPFC) and impaired functional connectivity between these two regions. DMPFC-basal ganglia mediated the effect of plasma and CSF KP on anhedonia. These findings highlight the pathological...
This invention relates to methods of reducing blood levels of cholesterol, and more particularly the reduction of low-density lipoprotein (LDL) cholesterol. The invention involves oral administration of a therapeutic agent for decreasing plasma cholesterol concentration. ...