BEIJING, Feb. 20 (Xinhua) -- Chinese researchers have identified a group of plasma proteomic profiles to predict the risk of dementia 15 years earlier before the disease is detected, according to a recent research article published in the journal Nature Aging. The advent of proteomics offers an...
The advent of proteomics offers an unprecedented opportunity to predict dementia onset. We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 incident cases and a follow-up time of 14.1 years. Of 1,463 plasma prote
A single plasma protein is unlikely to predict the risk of multiple disease events simultaneously. Overcoming the hurdles of proteomic techniques, the risk score we constructed, based on 1461 proteins, stratified risk trajectories well for all endpoints studied. We modeled the score on the process p...
et al. Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants. Alz Res Therapy 16, 16 (2024). https://doi.org/10.1186/s13195-023-01379-3 Download citation Received19 October 2023 Accepted30 December 2023 Published22 January 2024 ...
Presently, the mainstay methods to identify AMS biomarkers include proteomic and genetic methods at high altitudes or in hypoxic simulated chambers. In the present study, we compared plasma cytokine profiles between AMS-susceptible individuals and AMS-resistant individuals at low altitude by cytokine ...
Among gynaecological malignancies, endometrial cancer (EC) is the most prevalent type of uterine cancer affecting women. This study explored the proteomic profiles of plasma samples obtained from EC patients, those with hyperplasia (Hy), and a control gr
Broad-capture proteomic platforms now enable simultaneous assessment of thousands of plasma proteins, but most of these are not actively secreted and their origins are largely unknown. Here we integrate genomic with deep phenomic information to identify
Plasma proteomic profiles predict future dementia in healthy adults. Nat. Aging 4, 247–260 (2024). Article CAS PubMed Google Scholar Tsai, V. W. W., Husaini, Y., Sainsbury, A., Brown, D. A. & Breit, S. N. The MIC-1/GDF15-GFRAL pathway in energy homeostasis: implications for...
Article Open access 10 July 2024 Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals Article Open access 25 February 2021 Plasma proteomic profiles predict individual future health risk Article Open access 28 November 2023 Main...
and duration of response is independent from the currently known variables that can predict the same thing. If the proteomic data adds to the model that includes the conventional markers, the p-value will be significant, but if the proteomic data does not add to the model and similar predictio...