Identification of unique cell surface markers on myeloma cells is important for development of targeted therapies and detection of residual disease. GPRC5D is an orphan receptor reportedly expressed at high level in bone marrow (BM) aspirates or biopsies from myeloma patients. Other studies detected ...
Stages of plasma cell maturation have been defined by numerous observations in different locations and at different stages of immune responses[1]. This ranges from alterations incell surface markers, sensitivity to chemotactic signals, and the capacity to secrete antibody. However, the relationship betwe...
Plasma CellAntigen PC-1p class=Style4The murine plasma cell antigen PC-1 is a cell surface glycoprotein which is disulfic-bond homodimer of Mr 115 kD. It is expressed in large amounts of neoplastic plasma cell and on the majority of haemolytic plaque-forming cellssup1/sup. It is also ...
nature publishing group Clinical Investigation Articles Plasma cytokines and markers of endothelial activation increase after packed red blood cell transfusion in the preterm infant Amy K. Keir1, Andrew J. McPhee1,2, Chad C. Andersen1,2 and Michael J. Stark1,2 Background: Transfusion of ...
CELL SURFACE MARKER ANALYSIS OF 'LYMPHOID'AND MYELOID CASES SUMMARY. Fourteen cases of Philadelphia chromosome (Ph 1 ) positive chronic myeloid leukaemia in blast transformation have been investigated using cell surface markers. Morphologically eight cases were lymphoid and the remainder myeloid ... G ...
were subjected to flow analysis for MSC cell surface markers46using CytoFlex cytometer (Beckman Coulter); these cells appeared as pure populations of CD90+CD73+CD45-CD19−and were classified as primary BM-MSC. These MSC were further propagated generally between their third and eight passages. ...
In individual patients, myeloma cells expressing lineage- and differentiation-associated surface mol... J Epstein - 《Hematology/oncology Clinics of North America》 被引量: 38发表: 1997年 Plasma Cell Neoplasms: MGUS and Myeloma Neoplasms of plasma cells are a group of diseases characterized by the...
Besides, ROS mediated oxidative stress can induce cell apoptosis of osteocyte and osteoblast [27, 28]. 8-OHdG, one of the most pivotal markers of oxidative stress, has been used to measure the effect of endogenous oxidative damage to DNA [29]. Recently, 8-OHdG has been used as biomarker ...
p class=Style4The murine plasma cell antigen PC-1 is a cell surface glycoprotein which is disulfic-bond homodimer of Mr 115 kD. It is expressed in large amounts of neoplastic plasma cell and on the majority of haemolytic plaque-forming cellssup1/sup. It is also found in non-lymphoid ti...
26,34 As mice age, there appears to be an increase in the fraction of cells with cell-surface markers associated with plasma cell longevity,26,34 and this is re-established over months following plasma cell depletion.26 Finally, the surface expression of CXCR4, which promotes motility toward ...