Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). Fifty-five patients with HCC who received RT were recruited from two prospective study...
Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random fragmentation procedure. Despite commendable translational values in cancer liquid biopsy, however, the biology of cfDNA, especially the principles of cfDNA fragmentation, remains largely elusive. Through orientation-aware anal...
aCell-free fetal DNA in maternal plasma presents interest as it can possibly serve as a pregnancy associated biomarker. For its quantitation, we investigate the use of fluorescent polymerase chain reaction (PCR) amplification of short tandem repeats (STRs) in pregnancies irrespective of sex. 当它...
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Circulating cell-free DNA (cfDNA, liquid biopsy) is a powerful tool to detect molecular alterations. However, depending on tumor characteristics, biology and anatomic localization, cfDNA detection and analysis may be challenging. Gliomas are enclosed into an anatomic sanctuary, which obstacles the relea...
cfDNA, cell-free DNA; EQ, EpiQuick Circulating Cell-Free DNA Isolation Kit (EpiGentek, Farmingdale, NY); NpMV1, NEXTprep-Mag cfDNA Isolation Kit (SanBio B.V., Uden, the Netherlands); NpMV2, second, consecutive version of the NpM kit (SanBio B.V.); PME, PME free-circulating DNA Ext...
Cell-free DNA Drug therapy Cystic echinococcosis Echinococcus granulosus High-throughput sequencing 1. Introduction Over one million people are living with cystic echinococcosis (CE) and alveolar echinococcosis (AE), with over 200,000 additional cases per year [1,2]. The causative agents, Echinococcus...
et al. Genomic alterations in cell-free DNA and enzalutamide resistance in castration-resistant prostate cancer. JAMA Oncol. 2, 1598–1606 (2016). PubMed PubMed Central Google Scholar De Mattos-Arruda, L. et al. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of ...
The use of liquid biopsies for cancer detection and management is rapidly gaining prominence1. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA, but the sensitivity of these methods may
Accurate identification of tumor-derived somatic variants in plasma circulating cell-free DNA (cfDNA) requires understanding of the various biological compartments contributing to the cfDNA pool. We sought to define the technical feasibility of a high-intensity sequencing assay of cfDNA and matched white...