The invention relates to novel biological markers for plasma cell disorders, such as multiple myeloma, and in particular to the use of microRNAs as diagnostic and prognostic markers
However, the molecular abnormalities identified in PCM are not unique to this disorder, and may also be found in other plasma cell neoplasms, such as plasma cell leukemia or solitary plasmacytomas. For this reason, molecular studies do not assist in the classification of plasma cell neoplasms. ...
In classical terms, a plasma cell is a terminally differentiated B lymphocyte, and a myeloma cell is its neoplastically transformed progeny. These are simplistic definitions, for plasma cell disorders (PCDs) are a complex group comprising a diverse spect
LPC, an inflammatory phospholipid generated by hydrolysis of PC via the actions of phospholipase A2 (PLA2), promotes inflammatory effects such as expression of endothelial cell adhesion molecules, growth factors, chemotaxis and activation of monocytes/macrophages.25 LPC has been suggested to have a ...
Liver and bone marrow have been reported to contribute heavily to the abundance of cell-free nucleic acids in plasma42,45,46. This may explain the source of cfRNA biomarkers found in these cancer types. In HCC, eight out of the top ten genes used in the classification model are specificall...
A plasma cell neoplasm is defined as an abnormal clonal plasma cell proliferation invading bone marrow, blood, and other organs or tissues.1 Depending on the clinical presentations and laboratory findings, plasma cell neoplasms, according to the 2022 World Health Organization (WHO) Classification, ...
(CIBERONC), CB16/12/00233, 28029 Madrid, Spain 4 Grupo Español de Mieloma (GEM), 28040 Madrid, Spain * Correspondence: normagu@usal.es; Tel.: +34-923-291-200 (ext. 56617) Simple Summary: Plasma cell leukemia (PCL) is a very aggressive plasma cell disorder with a dismal prognosis...
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Both proteins play roles in regulating endothelial cell function and angiogenesis, and they have been implicated in processes related to inflammation and vascular disease [75, 76]. Furthermore, we observed an elevation in Colony-Stimulating Factor 1 (CSF1) in the plasma of individuals with AD. ...
While the psychiatric symptoms of schizophrenia can be managed by current antipsychotic medications, there is room for improvement in the management of other aspects of the disorder, such as the cognitive deficits and significantly reduced lifespan seen in persons with schizophrenia. Despite the presence...