A review on the mo- lecular mechanisms involved in the placental barrier for drugs. Curr Drug Deliv 2004; 1(3): 275-89.J.J.G. Marin, O. Briz, M.A. Serrano, A review on the molecular mechanisms involved in the placental barrier for drugs, Curr. Drug Deliv. 1 (2004) 275-289....
warranting further studies that perfuse different caffeine concentrations across the placental barrier. Their model also provides a platform for examining the safety of drugs administered to pregnant women.
and caffeine is a central nervous system stimulant. They are widely used as reference drugs in ex vivo placental perfusion systems and cross the placental barrier by passive diffusion48. Glyphosate, a commonly used herbicide, has a significantly lower permeation rate in these systems. We used the ...
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996;97(11):2517–24. Article CAS PubMed PubMed Central Google Scholar Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR. Placental P-...
Thefetoplacental unithas three important functions: (i) a source of protein andsteroid hormones, which are delivered to the maternal circulation; (ii) a selective barrier that determines the nature of the communication and interaction between the maternal and fetalendocrinological and physiological syste...
15 These cytokines have direct access to the placenta via maternal blood, and signaling may be propagated across the placental barrier through stimulation of inflammation within the placenta.16 Direct passage of maternal cytokines through the placenta is also possible, at least for a subset of ...
Trophoblast cells are an important component of the placental barrier,placental barrier is the only way to the baby from the mother for nutrients,drugs,viruses,and so on,it's related to the recurrent spontaneous abortion and other obstetric diseases.In addition,trophoblast cells also have endocrine...
In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier The placenta barrier comprises a dynamic fetal:maternal interface for controlling the exchange of essential nutrients, gases, metabolic wastes, toxins, and drugs. Long considered a "leaky" filter, the P Mitra,KL Audus 被引...
The secretory immune system as part of the placental barrier in the second trimester of pregnancy in humans. The objective of this study was to describe the development of the secretory immune system (SIS) in the placenta of 32 human fetuses who had died from diff... H Ben-Hur,P Gurevich...
We also present analyses of the transplacental transfer and placental distribution characteristics of each class of compounds, and discuss effects of several factors on the transfer and accumulation efficiencies of HOPs, as well as the main mechanisms of HOPs’ transfer across the placental barrier. ...