Studies on the increasing number of transporters found in the placental barrier are gaining momentum, because of their tissue-specific expression, significance in physiology and disease, and the possible utilization of the emerging knowledge in pharmacology. In the placenta, both syncytiotropho...
2016). Morphological changes can be indicative of functional adaptation: the surface area, the thickness of the placental barrier, and the architectural arrangements of the placental vasculature for the exchange of materials between the maternal and fetal environment (Zhang et al. 2015). Placental ...
Dust, soot, and bacteria are filtered out by a barrier ofcilia, tiny hairlike processes that line the passageways of the respiratory tract. The cilia trap not only foreign particles but also mucus produced by the respiratory passages themselves. Since the movement of the cilia is always toward...
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996;97(11):2517–24. Article CAS PubMed PubMed Central Google Scholar Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR. Placental P-...
2. The placenta barrier to drugs and teratogens 3. Bacterial infection and placental MDR transporters 4. Viral infection and placental MDR transporters 5. Malarial infection and placental multidrug resistance (MDR) transporters 6. Polymicrobial infection and placental multidrug resistance (MDR) transporters...
The placenta also functions as a physiological barrier that protects the fetus against injurious influences from the mother (selective retention by the placenta of certain harmful substances circulating in the maternal blood). On the other hand, some chemical compounds, drugs in particular, that are ...
Heparin neutralization by an extract of the human placenta: measurements and the concept of placental barrier to heparin. A soluble extract from human placenta was found to neutralize heparin in a factor Xa-dependent heparin assay system. In comparison with serum the antihepar... Mieczysław Us...
Chapter Onnen, I.; Barrier, G.; d'Athis, P.; Sureau, C.; Olive, G. European Journal of Clinical Pharmacology 15(6): 443-446 1979 ISSN/ISBN:0031-6970 499293 10.1007/bf00561745 006125019 Article emailed within 0-6 h Buy Now for$19.90 ...
Given the broad application of fullerenols and their potential to cross the placental barrier (as nanoparticles), further investigation is warranted into the safety, toxicity, and particularly the embryotoxicity of fullerenols. This study established a pregnancy mouse exposure model using metabolomics ...
Also, the extent to which antipyrine and paracetamol permeate the placental barrier can be compared to data collected from placental explants and the in vitro placenta device's cell culture for the same drugs. Transport parameters can be normalized by surface area for the in vitro model, cell ...