A review on the mo- lecular mechanisms involved in the placental barrier for drugs. Curr Drug Deliv 2004; 1(3): 275-89.J.J.G. Marin, O. Briz, M.A. Serrano, A review on the molecular mechanisms involved in the placental barrier for drugs, Curr. Drug Deliv. 1 (2004) 275-289....
Placental and blood-brain barrier transfer following prenatal and postnatal exposures to neuroactive drugs: relationship with partition coefficient and behavioural teratogenesis. Toxicol Appl Pharmacol 1990;105:66- 77.Watanabe, et al. 1990. Placental and blood-brain barrier transfer fol- lowing prenatal ...
Results: During pregnancy, several drugs and chemicals can be transferred from the mother to the fetus across the placental barrier by either passive diffusion or through placental transporters, resulting in fetus exposure and potential fetotoxicity effects. Some drugs and chemicals also appear to be ...
In terms of safety, in addition to the anticipated adverse events associated with AR inhibitors, rare occurrences of seizures and posterior reversible encephalopathy syndrome have been reported, which is likely due to the drug crossing the blood–brain barrier. The most common adverse reactions ...
Peters and Heidushka tried to demonstrate that bevacizumab was also eliminated through the posterior route crossing the blood-retinal barrier. They observed that bevacizumab immunoreactivity after the intravitreal injection extended over time to the inner layers of the retina. However, they did not ...
ZIKV has also tropism for placental tissue, which may explain its teratogenicity [1]. As shown in Table 1, ZIKV infection has been associated with cases of microcephaly and other congenital malformations [4]. In adults, severe neurologic complications of infection described include Guillain- Barré...
Moreover, exosomes can cross the blood–brain barrier [12,13] and the placental barrier [14,15]. Their ability to cross the blood–brain barrier can be used to develop delivery systems to brain tissue, for example, in Alzheimer’s and Parkinson’s disease [16]. Exosomes have been found ...